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    BIOMARKER:

    IFNG 6-gene signature

    6ms
    Immuno-oncologic signature of malignant transformation in oral squamous cell carcinoma. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol)
    Our work suggests a role for IFN-γ in PD-L1 upregulation in OPMC and presents novel IO transcriptional signatures for frankly invasive OSCC relative to TM.
    Journal • PD(L)-1 Biomarker • IO biomarker • Immuno-oncology
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • LAMC2 (Laminin subunit gamma 2) • CGAS (Cyclic GMP-AMP Synthase) • MMP1 (Matrix metallopeptidase 1) • OASL (2'-5'-Oligoadenylate Synthetase Like) • TDO2 (Tryptophan 2,3-Dioxygenase) • ADAM12 (ADAM Metallopeptidase Domain 12) • CNTFR (Ciliary Neurotrophic Factor Receptor) • COL5A1 (Collagen Type V Alpha 1 Chain)
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    PD-L1 expression • IFNG 6-gene signature • 6-gene signature