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    GENE:

    IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)

    i
    Other names: IFIT2, Interferon Induced Protein With Tetratricopeptide Repeats 2, Interferon-Induced Protein With Tetratricopeptide Repeats 2, ISG-54K, GARG-39, IFI-54, Cig42, G10P2, IFI54, Interferon-Induced 54 KDa Protein, ISG-54 K, IFI-54K, ISG-54, IFIT-2, ISG54, P54, Interferon, Alpha-Inducible Protein (MW 54kD), Interferon-Induced Protein 54, CIG-42
    Associations

    News

    Trials
    23d
    IL-6 as a driver of bone invasion in IFIT2-depleted oral squamous cell carcinoma. (PubMed, Cancer Immunol Immunother)
    Notably, a high IL-6/IFIT2 ratio was associated with reduced median survival among OSCC patients. These findings indicate that IFIT2 depletion enhances OSCC-induced bone invasion predominantly through IL-6-mediated osteoclast activation, establishing the IL-6/IFIT2 axis as a critical regulator of OSCC progression and metastasis.
    Journal
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    IL6 (Interleukin 6) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    1m
    SPIB suppresses protective autophagy via the IFIT2/PINK1/Parkin axis to promote anoikis in colorectal cancer. (PubMed, Cancer Cell Int)
    Our results demonstrate that SPIB exerts tumor-suppressive effects during CRC invasion and metastasis through the IFIT2/PINK1/Parkin axis. This study highlights SPIB as a potential therapeutic target for overcoming anoikis resistance in CRC therapy.
    Journal
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    IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    2ms
    Basic Science and Pathogenesis. (PubMed, Alzheimers Dement)
    Our pilot study demonstrated the feasibility of generating high-quality, large-scale single-cell multi-omic data from the human amygdala. We observed abundant AD-associated microglia in amygdala, suggesting the possibility that the regional vulnerability of amygdala to multiple neurodegenerative disorders might be in part due to different glial composition.
    Journal
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    TARDBP (TAR DNA Binding Protein) • APOE (Apolipoprotein E) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • TREM2 (Triggering Receptor Expressed On Myeloid Cells 2)
    3ms
    Stimulator of interferon genes signaling network-driven prognostic signature for pancreatic cancer: Hub gene discovery with multimodal validation. (PubMed, Oncol Lett)
    Subsequent functional experiments involving knockout of IFIT2 and overexpression of ZDHHC1in PAAD cell lines demonstrated that these genes significantly regulated cell proliferation (assessed by CCK-8 assay) and apoptosis (assessed by TUNEL assay) (P<0.001). In summary, the STING signaling pathway is critically involved in PAAD pathogenesis, and the representative genes IFIT2 and ZDHHC1 exhibit distinct functional roles within this context.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • STING (stimulator of interferon response cGAMP interactor 1) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    5ms
    Therapeutic potential of IFIT2 in human diseases. (PubMed, Cytokine)
    Although its mechanistic functions in numerous diseases remain only partly understood, IFIT2 emerges as a versatile immune effector with considerable translational promise. Further investigation into its biological roles will be crucial for utilising its therapeutic potential across infectious, inflammatory, metabolic, and neoplastic diseases.
    Review • Journal
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    IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    8ms
    BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells. (PubMed, Oncol Lett)
    The results of the present study demonstrated that BLID is a target of FOXO3a, and BLID-deficiency in breast cancer cells was associated with modulation of cell death, survival and proliferation, chemoresistance, drug potency, and the interferon response. These findings highlighted BLID as a promising biomarker of drug response and offer a novel framework of integrative mechanisms of therapeutic resistance and disease progression.
    Journal
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    PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • BIRC3 (Baculoviral IAP repeat containing 3) • FOXO3 (Forkhead box O3) • GSDME (Gasdermin E) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • IFNB1 (Interferon Beta 1)
    8ms
    Clinical Utility of IFIT Proteins in Human Malignancies. (PubMed, Biomedicines)
    Additionally, they have also been reported to be a part of various clinical predictive models in cancers. This review provides an overview of the current understanding of IFIT proteins' involvement in cancers, with an emphasis on their emerging roles as clinically relevant biomarkers.
    Review • Journal • IO biomarker
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    10ms
    Transcriptome insights into newcastle disease virus-mediated eradication of cholangiocarcinoma cells. (PubMed, PLoS One)
    In addition, gene network analysis highlighted CCNA2, CDK1, DDX58, DHX58, EXO1, GBP1, IFIH1, IFIT1, IFIT2, IFIT3, IRF7, ISIG15, MX1, OAS1, OAS2, PARP9, TOP2A and XAF1 as potential hub genes influencing the response of CCA cells to NDV LaSota strain. Our findings offer evidence supporting the promise of NDV-based therapies as potential strategies for eliminating CCA cells.
    Journal • PARP Biomarker
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • TOP2A (DNA topoisomerase 2-alpha) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TGM2 (Transglutaminase 2) • CCNA2 (Cyclin A2) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • CDK1 (Cyclin-dependent kinase 1) • GBP1 (Guanylate Binding Protein 1) • IFIH1 (Interferon Induced With Helicase C Domain 1) • DDX58 (DExD/H-Box Helicase 58) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • IRF7 (Interferon Regulatory Factor 7) • MX1 (MX Dynamin Like GTPase 1) • XAF1 (XIAP Associated Factor 1)
    10ms
    Correlation Analysis Between IFIT2 and HLA Class II in Oral Cancer. (PubMed, Anticancer Res)
    HLA class II expression may be positively correlated with IFIT2 expression in oral cancer cells. Clinically, low expression of HLA II molecules may be related to lymph node metastasis in oral cancer patients.
    Journal
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    IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    over1year
    Exploration of the link between COVID-19 and gastric cancer from the perspective of bioinformatics and systems biology. (PubMed, Front Med (Lausanne))
    More importantly, we identified ten potential therapeutic agents, including ciclopirox, resveratrol, etoposide, methotrexate, trifluridine, enterolactone, troglitazone, calcitriol, dasatinib and deferoxamine, some of which have been reported to improve and treat GC and COVID-19. This research offer valuable insights into the molecular interplay between COVID-19 and GC, potentially guiding future therapeutic strategies.
    Journal
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    PLK1 (Polo Like Kinase 1) • CDK1 (Cyclin-dependent kinase 1) • CENPA (Centromere protein A) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • KIF20A (Kinesin Family Member 20A) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
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    dasatinib • etoposide IV • methotrexate
    over1year
    Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer. (PubMed, Front Cell Dev Biol)
    MORC3 knockdown also increased the expression of cellular proliferation-related genes and promoted cancer cell proliferation. The present study demonstrated that MORC3 regulates IFN-associated pathways and is a novel repressor of PD-L1 expression and cancer cell proliferation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFIH1 (Interferon Induced With Helicase C Domain 1) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • IRF7 (Interferon Regulatory Factor 7)
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    PD-L1 expression
    over1year
    The Role of Interferon-Induced Proteins with Tetratricopeptide Repeats 1 and 2 in Sepsis-Induced Acute Liver Injury. (PubMed, Infect Drug Resist)
    Moreover, the expression of IFIT1 and IFIT2 was both negatively related to the levels of TNF-α (r = -0.5027, p < 0.0001; r = -0.4218, p < 0.0001), IL-1β (r = -0.3349, p = 0.0002; r = -0.4070, p < 0.0001) and IL-6 (r = -0.2734, p = 0.0030; r = -0.3536, p < 0.0001), respectively. IFIT1 and IFIT2 can serve as the diagnostic markers for sepsis-related liver injury, and IFIT1 and IFIT2 may participate in the pathological process of sepsis-related liver injury by regulating inflammation and liver function.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • IL1B (Interleukin 1, beta) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)