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    GENE:

    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)

    i
    Other names: IFIT1, Interferon Induced Protein With Tetratricopeptide Repeats 1, Interferon-Induced Protein With Tetratricopeptide Repeats 1, Interferon-Induced 56 KDa Protein, IFI-56K, IFIT-1, IFNAI1, G10P1, IFI56, ISG56, P56, Interferon, Alpha-Inducible Protein (MW 56kD), Interferon-Inducible MRNA 561, GARG-16, IFI-56, RNM561, IFIT1, C56
    8d
    RNA and ChIP-sequencing analysis reveals SOX3 suppresses antiviral innate immunity through the AKT1-PTEN signaling axis. (PubMed, Virol Sin)
    Inactivation of PTEN inhibited interferon regulatory factor 3 (IRF3) nuclear translocation, leading to reduced IFN-β expression. Thus, our findings uncover a previously uncharacterized SOX3-AKT1-PTEN signaling axis in the regulation of antiviral innate immunity, providing new insights into immune evasion strategies and highlighting potential therapeutic targets to enhance antiviral responses.
    Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • SOX2 • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • IFNB1 (Interferon Beta 1)
    11d
    Immune transcriptomic changes in Australian Gulf War veterans. (PubMed, PLoS One)
    This investigation elucidates the potential role of immune dysregulation underlying GWI, emphasising the importance of immune exhaustion pathways in disease progression. Further investigations in a larger cohort may further elucidate or confirm these identified markers for potential screening or therapeutic applications in GWI.
    Journal • IO biomarker
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • MMP9 (Matrix metallopeptidase 9) • CEACAM1 (CEA Cell Adhesion Molecule 1) • IGHG1 (Immunoglobulin Heavy Constant Gamma 1) • IL7 (Interleukin 7) • SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1)
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    nCounter® Immune Exhaustion Panel
    24d
    Transcriptomic analysis reveals TME-mediated macrophage IFIT1 upregulation and CX3CR1 suppression drive osteosarcoma progression. (PubMed, Front Oncol)
    Stimulation of the OS TME can change the gene expression of macrophages. Our findings offer a cellular and molecular reference for future investigations of therapeutic targets of OS.
    Journal
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1)
    24d
    Single-cell RNA sequencing reveals age-related heterogeneity in the tumor microenvironment of breast cancer patients. (PubMed, Sci Rep)
    Despite limited sample size, the combination of single-cell transcriptomics, clinical survival data, and protein-level validation provides robust evidence of age-specific TME remodeling. These findings support the development of age-tailored immunotherapy strategies targeting interferon signaling in young patients and immune checkpoint pathways (e.g., LAG3, CTLA4) in elderly individuals.
    Journal • IO biomarker
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    LAG3 (Lymphocyte Activating 3) • SPP1 (Secreted Phosphoprotein 1) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)
    26d
    NK cell allorecognition shapes reprogramming of neutrophils infiltrating heart allografts. (PubMed, bioRxiv)
    Mechanistically, NK cell-mediated innate allorecognition drives this early intra-allograft specific neutrophil phenotypic programing. These findings provide novel insights into the innate immune allorecognition-mediated regulation of the plasticity of recently described key neutrophil subsets and will enable specific targeting to neutralize detrimental neutrophil subsets and enhance solid organ transplant outcomes.
    Journal
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    TNFRSF10A (TNF Receptor Superfamily Member 10a) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)
    1m
    Single-cell RNA sequencing in osteosarcoma: applications in diagnosis, prognosis, and treatment. (PubMed, Med Oncol)
    Additionally, it uncovered promising drug candidates-etoposide, mevastatin, oxfendazole, HDAC inhibitors, and TIGIT blockade-as well as immunotherapies like PD-1 inhibition and adoptive CD8+ T cell therapy...While technical challenges remain, it paves the way for more personalized and effective treatment strategies. However, the current findings are subject to limitations, including technical biases in single-cell protocols and the exclusion of non-English literature, which may affect generalizability.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • MCL1 (Myeloid cell leukemia 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD24 (CD24 Molecule) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • SERPINE1 (Serpin Family E Member 1) • TXNIP (Thioredoxin Interacting Protein) • TNFSF11 (TNF Superfamily Member 11)
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    etoposide IV
    2ms
    Study on the effect of ATPIF1 on the anti-tumor activity of CAR-NK92 cells by regulating glycolytic capacity (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    The impact of glycolytic inhibition by 2-Deoxy-D-glucose (2-DG) on CAR-NK92 antitumor capacity was examined...Conclusion ATPIF1 regulates the antitumor activity of CAR-NK92 cells through modulating glycolytic metabolism. Overexpression of ATPIF1 can enhance the antitumor efficacy of CAR-NK92 cells.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • LAMP1 (Lysosomal Associated Membrane Protein 1) • GZMB (Granzyme B) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • ATP5IF1 (ATP Synthase Inhibitory Factor Subunit 1) • NKG2D (killer cell lectin like receptor K1)
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    HER-2 overexpression
    6ms
    Whole-Genome and RNA Sequencing Reveal Novel Insights into the Pathogenesis of Colorectal Cancer in Persons Living with HIV. (PubMed, AIDS Res Hum Retroviruses)
    We found highly analogous insertions, deletions, and functional annotations of the detected single nucleotide polymorphisms and indel mutations in PWH and patients with HIV-negative CRC. This study provides new insights into crucial ISGs, immune infiltration, immune variants, and pathways involved in CRC with HIV infection.
    Journal
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    FGF2 (Fibroblast Growth Factor 2) • EGF (Epidermal growth factor) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • CCL3 (C-C Motif Chemokine Ligand 3) • MX1 (MX Dynamin Like GTPase 1)
    6ms
    Clinical Utility of IFIT Proteins in Human Malignancies. (PubMed, Biomedicines)
    Additionally, they have also been reported to be a part of various clinical predictive models in cancers. This review provides an overview of the current understanding of IFIT proteins' involvement in cancers, with an emphasis on their emerging roles as clinically relevant biomarkers.
    Review • Journal • IO biomarker
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2)
    6ms
    The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein. (PubMed, Cell Mol Life Sci)
    We conclude that the interactions between p53 and interferon-activated pathways are more complicated than initially expected, and their cooperation deserves further investigation. Moreover, we found that SOCS1 can be either up- or down-regulated by p53 depending on cell type and stress conditions.
    Journal
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    TP53 (Tumor protein P53) • IFNG (Interferon, gamma) • SOCS1 (Suppressor Of Cytokine Signaling 1) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • IFNA1 (Interferon Alpha 1)
    6ms
    Integrative Analysis of Shared Pathogenic Genes and Potential Mechanisms in Gardnerella vaginalis and Persistent HPV16 Infection. (PubMed, Mediators Inflamm)
    Notably, single-cell transcriptomics revealed distinct RSAD2 and IFIT1 expression patterns in immune and epithelial cells during the progression from HPV infection to cervical cancer. Collectively, these findings support RSAD2 and IFIT1 as promising biomarkers and therapeutic targets for HPV-related cervical lesions.
    Journal
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    IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1)
    7ms
    Transcriptome insights into newcastle disease virus-mediated eradication of cholangiocarcinoma cells. (PubMed, PLoS One)
    In addition, gene network analysis highlighted CCNA2, CDK1, DDX58, DHX58, EXO1, GBP1, IFIH1, IFIT1, IFIT2, IFIT3, IRF7, ISIG15, MX1, OAS1, OAS2, PARP9, TOP2A and XAF1 as potential hub genes influencing the response of CCA cells to NDV LaSota strain. Our findings offer evidence supporting the promise of NDV-based therapies as potential strategies for eliminating CCA cells.
    Journal • PARP Biomarker
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • TOP2A (DNA topoisomerase 2-alpha) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TGM2 (Transglutaminase 2) • CCNA2 (Cyclin A2) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • CDK1 (Cyclin-dependent kinase 1) • GBP1 (Guanylate Binding Protein 1) • IFIH1 (Interferon Induced With Helicase C Domain 1) • DDX58 (DExD/H-Box Helicase 58) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • IRF7 (Interferon Regulatory Factor 7) • MX1 (MX Dynamin Like GTPase 1) • XAF1 (XIAP Associated Factor 1)