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BIOMARKER:

IFIT1 overexpression

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Other names: IFIT1, Interferon Induced Protein With Tetratricopeptide Repeats 1, Interferon-Induced Protein With Tetratricopeptide Repeats 1, Interferon-Induced 56 KDa Protein, IFI-56K, IFIT-1, IFNAI1, G10P1, IFI56, ISG56, P56, Interferon, Alpha-Inducible Protein (MW 56kD), Interferon-Inducible MRNA 561, GARG-16, IFI-56, RNM561, IFIT1, C56
Entrez ID:
6ms
Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3. (PubMed, Cancer Sci)
The antitumor effect of gefitinib on orthotopic TW2.6/LOXL2 xenograft tumor was fourfold higher than that on controls. Our results indicate that LOXL2 expression is a strong prognostic factor for OSCC and may be used as a marker to identify patients most likely to respond to EGFR-targeted therapy.
Journal
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IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • LOXL2 (Lysyl Oxidase Like 2)
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IFIT1 overexpression • IFIT3 overexpression
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gefitinib
over1year
circIFITM1/miR-802/Foxp1 Axis Participates in Proliferation and Invasion of Lovo Cells. (PubMed, Dis Markers)
The cyclicity of circIFITM1 was confirmed by agarose gel electrophoresis and Sanger sequencing, and the stability of circIFITM1 was confirmed by actinomycin D assay...The overexpression of circIFITM1 downregulated miR-802 and upregulated FOXP1. circIFITM1 facilitates the proliferative and invasive abilities via miR-802/FOXP1 in Lovo cells.
Journal
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FOXP1 (Forkhead Box P1)
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IFIT1 overexpression • FOXP1 overexpression
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dactinomycin
2years
The Highly Expressed IFIT1 in Nasopharyngeal Carcinoma Enhances Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells. (PubMed, Mol Biotechnol)
In conclusion, a total of 49 DEGs and 11 hub genes in NPC using the integrated bioinformatics analysis. IFIT1 was up-regulated in the NPC cells lines, and IFIT1 may act as an oncogene by promoting NPC cell proliferation, migration, and invasion.
Journal
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CXCL11 (C-X-C Motif Chemokine Ligand 11) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • COL22A1 (Collagen Type XXII Alpha 1 Chain) • COL5A1 (Collagen Type V Alpha 1 Chain)
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IFIT1 overexpression
almost3years
Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression. (PubMed, Cancer Lett)
Notably, siRNA knockdown of p65 reduces IFITM1 expression and a drug-repurposing screen of FDA approved compounds identified parthenolide, an NFκB inhibitor, as a cytotoxic agent for TNBC and an inhibitor of IFITM1 in vitro and in vivo. Overall, our findings suggest that targeting IFITM1 by suppressing interferon-alpha/NFκB signaling represents a novel therapeutic strategy for TNBC treatment.
Journal
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NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • RELA (RELA Proto-Oncogene)
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IFIT1 overexpression