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    BIOMARKER:

    IFI35 overexpression

    i
    Other names: IFI35, Interferon Induced Protein 35, Interferon-Induced 35 KDa Protein, IFP 35
    Entrez ID:
    3430
    over2years
    Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8 T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer. (PubMed, J Biomed Sci)
    Our findings identify IFI35 as a new biomarker that can enhance the proliferation and function of CD8 T cells, as well as increase the efficacy of CAR-T cells against colorectal cancer cells.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFI35 (Interferon Induced Protein 35) • IRF7 (Interferon Regulatory Factor 7)
    |
    IFI35 overexpression
    over2years
    IFI35 promotes cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer (IDDF 2023)
    Tumor IFI35 promotes CD8 T cell effector cytokines as well as anti-tumor immunotherapy efficacy for CRC). Conclusions Our findings identify IFI35 as a new biomarker that can enhance the number and function of CD8 + T cells, as well as increase the efficacy of immunotherapy for CRC patients.
    PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFI35 (Interferon Induced Protein 35) • IRF7 (Interferon Regulatory Factor 7)
    |
    IFI35 overexpression