^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    IFI16 overexpression

    i
    Other names: IFI16, Interferon Gamma Inducible Protein 16, IFNGIP1, Interferon-Inducible Myeloid Differentiation Transcriptional Activator, Gamma-Interferon-Inducible Protein 16, PYHIN2, Interferon-Gamma Induced Protein IFI 16, IFI16 Beta Isoform, Ifi-16
    Entrez ID:
    3428
    over4years
    Overexpression of Interferon-Inducible Protein 16 Promotes Progression of Human Pancreatic Adenocarcinoma Through Interleukin-1β-Induced Tumor-Associated Macrophage Infiltration in the Tumor Microenvironment. (PubMed, Front Cell Dev Biol)
    Depletion of TAMs by injection of liposome clodronate attenuated the IFI16 overexpression-induced tumor growth in PAAD. Additionally, knockdown of IFI16 could significantly potentiate gemcitabine treatment in PAAD, which may be associated with the reduced infiltration of TAMs in the tumor microenvironment. The findings of our study shed light on the role of IFI16 as a potential therapeutic target for PAAD.
    Journal
    |
    IFI16 (Interferon Gamma Inducible Protein 16) • IL1B (Interleukin 1, beta)
    |
    IFI16 overexpression
    |
    gemcitabine • clodronate disodium