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    BIOMARKER:

    ID3 underexpression

    i
    Other names: ID3, Inhibitor Of DNA Binding 3, HLH Protein, Inhibitor Of Differentiation 3, Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein, Class B Basic Helix-Loop-Helix Protein 25, DNA-Binding Protein Inhibitor ID-3, ID-Like Protein Inhibitor HLH 1R21, Helix-Loop-Helix Protein HEIR-1, BHLHb25, Inhibitor Of DNA Binding 3, BHLHB25, HEIR-1, HEIR1, 1R21
    Entrez ID:
    3399
    almost3years
    A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer. (PubMed, BMC Cancer)
    ID3 and PPARγ influence the radiosensitivity of colorectal cancer cells by interacting with MDC1 to form a positive feedback loop that promotes DNA damage repair. Patients with low expression of ID3 who received neoadjuvant chemoradiotherapy can obtain a better curative effect.
    Journal
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    PPARG (Peroxisome Proliferator Activated Receptor Gamma) • ID3 (Inhibitor Of DNA Binding 3, HLH Protein) • MDC1 (Mediator Of DNA Damage Checkpoint 1)
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    ID3 underexpression