^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    ICAM1 (Intercellular adhesion molecule 1)

    i
    Other names: ICAM1, BB2, CD54, Intercellular adhesion molecule 1
    2d
    Multi-omics analysis reveals that CAPG positive macrophages are key immunosuppressive drivers and prognostic determinants in the ferroptosis landscape of hepatocellular carcinoma. (PubMed, Discov Oncol)
    A prognostic model constructed from CAPG + Mac signature genes effectively stratified HCC patients into high- and low-risk groups and demonstrated stable predictive performance in external validation. This study reveals that CAPG + Mac putatively modulate ferroptosis signaling to influence immune homeostasis, highlighting them as a key target for HCC progression and immunotherapy responsiveness.
    Journal • IO biomarker
    |
    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • ICAM1 (Intercellular adhesion molecule 1) • ITGAX (Integrin Subunit Alpha X) • ITGB2 (Integrin Subunit Beta 2) • LGALS9 (Galectin 9)
    6d
    Noncatalytic Functions Are Required for MPO and PON1 in Modulating the Involvement of Monocytes and Endothelial Cells in Atherosclerosis. (PubMed, Biochem Res Int)
    The activation of THP-1 cells induced by MPO protein directly impaired in vitro microvascular structure via increasing the expression of IL-6 and TNFα regulated by NF-κB p65 of THP-1 cells. Together, the noncatalytic functions entail MPO and PON in modulating the involvement of monocytes and endothelial cells in atherosclerosis.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • ICAM1 (Intercellular adhesion molecule 1) • TERC (Telomerase RNA Component) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • MPO (Myeloperoxidase) • PON1 (Paraoxonase 1)
    7d
    Ze-qi Decoction Inhibits Neutrophil Extracellular Trap Formation to Suppress the Progression and Metastasis of Non-Small Cell Lung Cancer. (PubMed, Integr Cancer Ther)
    Our results indicate that the mechanisms of action of ZQD involve impeding neutrophil recruitment and activation, as well as reducing the levels of NETs-related markers. These suggest the potential of ZQD in suppressing NETs formation or release, inhibiting NSCLC progression and metastasis.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • ICAM1 (Intercellular adhesion molecule 1) • ITGB2 (Integrin Subunit Beta 2) • MPO (Myeloperoxidase)
    11d
    Mitochondrial Transfer in the Tumor Microenvironment. (PubMed, Cancer Sci)
    Future challenges include the development of specific and safe methods to manipulate mitochondrial transfer in vivo. Understanding mitochondrial transfer and its regulation may offer new avenues to overcome resistance and improve cancer outcomes.
    Review • Journal
    |
    ICAM1 (Intercellular adhesion molecule 1) • VCAM1 (Vascular Cell Adhesion Molecule 1)
    11d
    Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis. (PubMed, Int J Mol Sci)
    EVs enriched in platelet (CD49e) and endothelial (CD31) markers were associated with corticosteroid response, whereas EVs enriched with endothelial (CD105 and CD146) and B lymphocyte (CD19) markers were associated with mortality. Overall, EVs enriched in endothelial and monocyte markers may represent a candidate non-invasive tool for predicting corticosteroid response and mortality in AH, aiding risk stratification and early identification of non-responders for timely transplant evaluation.
    Journal • IO biomarker
    |
    CD20 (Membrane Spanning 4-Domains A1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • ICAM1 (Intercellular adhesion molecule 1) • CD14 (CD14 Molecule) • MCAM (Melanoma Cell Adhesion Molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • CD40 (CD40 Molecule) • ENG (Endoglin) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • ITGA5 (Integrin Subunit Alpha 5) • SELP (Selectin P)
    11d
    Modulation of Patient-Derived Tumor Organoids by SARS-CoV-2 Variants Across Cancer Types: A Study Combining Morphology, Inflammation, and Whole-Exome Profiling. (PubMed, Int J Mol Sci)
    Host gene variants involved in trafficking (FYCO1 and RAB7A) and immune signaling (FOXA2, SFTPD, STAT3, and TET2) were associated with differential infection profiles. These findings show that SARS-CoV-2 induces variant- and tumor-specific morphological and immunological changes in cancer PDOs, highlighting the potential of this model to unravel host-virus interactions and identify genetic factors that shape infection outcomes in cancer.
    Journal
    |
    TET2 (Tet Methylcytosine Dioxygenase 2) • IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • ICAM1 (Intercellular adhesion molecule 1) • CCL4 (Chemokine (C-C motif) ligand 4) • IL17A (Interleukin 17A) • FOXA2 (Forkhead Box A2) • IFNA1 (Interferon Alpha 1) • IL13 (Interleukin 13)
    12d
    Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma. (PubMed, Angiogenesis)
    Chemoproteomic and biophysical analyses reveal that erianin targets P4HA1 at the Arg379 site within the α-ketoglutarate (α-KG) binding pocket, leading to downregulation of the HIF1α/SNAIL/SLUG pathway, thereby restoring endothelial integrity by stabilizing VE-cadherin-mediated junctions and upregulating ICAM1 to enhance T-cell adhesion. These findings highlight erianin's potential to overcome vascular barriers and reprogram the tumor microenvironment, providing a novel therapeutic strategy to enhance immunotherapy in GBM and other solid tumors.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • ICAM1 (Intercellular adhesion molecule 1) • SNAI2 (Snail Family Transcriptional Repressor 2) • CDH5 (Cadherin 5)
    12d
    Systemic Loss of FKBPL Uncovers Diabetes-Dependent Pathways of Myocardial and Vascular Injury. (PubMed, Arterioscler Thromb Vasc Biol)
    FKBPL-based peptide mimetic, AD-01 (1 nM), in high-glucose conditions, upregulated endothelial vcam1 and glut1 mRNA expression, independent of miR-302b-5p. FKBPL plays an important role in glucose metabolism, endothelial function, angiogenesis, cardiac inflammation and function, and could be explored as a therapeutic target of cardiovascular disease both in nondiabetes and diabetes settings using precision medicine approach.
    Journal
    |
    ICAM1 (Intercellular adhesion molecule 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • LCN2 (Lipocalin-2) • IL15 (Interleukin 15) • IL22 (Interleukin 22) • IL7 (Interleukin 7) • SIRT1 (Sirtuin 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CDH5 (Cadherin 5) • FKBP5 (FKBP Prolyl Isomerase 5) • MIR302B (MicroRNA 302b) • POSTN (Periostin) • SLC2A1 (Solute Carrier Family 2 Member 1) • LIF (LIF Interleukin 6 Family Cytokine)
    |
    Zanosar (streptozocin)
    13d
    The Interrelationship Between Cardiac Autonomic Activity and Low-Grade Inflammation in Subjects with Obesity and Prediabetes. (PubMed, Exp Clin Endocrinol Diabetes)
    An independent inverse relationship was found between PSNS tone and systolic blood pressure and CRP. However, after adjustment for BMI and/or body composition parameters, waist circumference was the only independent predictor of PSNS activity (p<0.0001), explaining 26% of its variation.This study demonstrates an inverse relationship between PSNS activity and both systolic blood pressure and CRP levels, though this association is largely mediated by visceral obesity.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • ICAM1 (Intercellular adhesion molecule 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CRP (C-reactive protein)
    13d
    Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming. (PubMed, Blood)
    Furthermore, phase separation activity of nucleoplasmic ZNF467 (npZNF467) is crucial for its mechanical reprogramming function, and ectopic npZNF467 expression enhances the engraftment capacity of MPPs. Our findings establish biomechanical regulation as an important determinant of stem cell identity and reveal new strategies for engineering stem cells with enhanced regenerative capacity.
    Journal
    |
    ICAM1 (Intercellular adhesion molecule 1)
    13d
    Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption (clinicaltrials.gov)
    P=N/A, N=30, Active, not recruiting, University of California, Davis | Trial completion date: Aug 2025 --> Aug 2026
    Trial completion date
    |
    ICAM1 (Intercellular adhesion molecule 1)
    14d
    CLEAR: Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome (clinicaltrials.gov)
    P=N/A, N=200, Recruiting, University of Bern
    New trial
    |
    ICAM1 (Intercellular adhesion molecule 1) • SDC1 (Syndecan 1)