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DRUG:

iC9.GD2.CAR.IL-15 T-cells

i
Other names: iC9.GD2.CAR.IL-15 T-cells, autologous iC9-GD2CAR-CD28-CD3zeta-IL-15-expressing T-lymphocytes, autologous ic9-gd2car-cd28-cd3zeta-il-15-expressing T-cells, iC9-GD2. CAR.IL-15 T, Autologous Activated T-Cells Expressing a 2nd Generation GD2 Chimeric Antigen Receptor, IL-15, and iCaspase9 Safety Switch, CAR T-Cells Targeting the GD2 With IL-15+iCaspase9
Associations
Company:
UNC Lineberger Comprehensive Cancer Center
Drug class:
IL-15R stimulant, GD2-targeted CAR-T immunotherapy
Associations
3ms
Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma (clinicaltrials.gov)
P1, N=18, Recruiting, UNC Lineberger Comprehensive Cancer Center | Trial primary completion date: Jun 2024 --> May 2025
Trial primary completion date • CAR T-Cell Therapy
|
IL15 (Interleukin 15)
|
cyclophosphamide • fludarabine IV • iC9.GD2.CAR.IL-15 T-cells
over1year
Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer (clinicaltrials.gov)
P1, N=24, Recruiting, UNC Lineberger Comprehensive Cancer Center | Not yet recruiting --> Recruiting
Enrollment open • CAR T-Cell Therapy
|
IL15 (Interleukin 15)
|
iC9.GD2.CAR.IL-15 T-cells
2years
Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer (clinicaltrials.gov)
P1, N=24, Not yet recruiting, UNC Lineberger Comprehensive Cancer Center
New P1 trial • CAR T-Cell Therapy
|
IL15 (Interleukin 15)
|
iC9.GD2.CAR.IL-15 T-cells
over2years
Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/Refractory Osteosarcoma (clinicaltrials.gov)
P1, N=18, Recruiting, UNC Lineberger Comprehensive Cancer Center | Trial completion date: Sep 2038 --> Jun 2039 | Trial primary completion date: Sep 2023 --> Jun 2024
Trial completion date • Trial primary completion date • CAR T-Cell Therapy
|
IL15 (Interleukin 15)
|
cyclophosphamide • fludarabine IV • iC9.GD2.CAR.IL-15 T-cells