hydroxychloroquine

Firstly, she was treated with cyclosporine (CsA), soon discontinued due to gastrointestinal intolerance. She was subsequently treated with steroid pulses, hydroxychloroquine (HCQ) and mycophenolate (MMF), without improvement...In September 2021 rituximab (RTX) was stopped at the first infusion due to gastrointestinal intolerance...Therapy with various Jak inhibitors was started (first tofacitinib, then baricitinib, finally upadacitinib), leading to improvement of cutaneous ulcers, but stopped every time after a few months due to gastrointestinal intolerance and dizziness...After twelve total infusions, constitutional, articular and cutaneous involvement remained in good control. This case suggests the potential efficacy of ANI in refractory anti-MDA5-positive DM not only on skin manifestation, but also on articular and lung involvement.

The second cycle of adjuvant chemotherapy (5-fluorouracil, epirubicin, cyclophosphamide) caused right-upper-limb phlebitis and lymphangitis with permanent damage to local vasculature...She was on hydroxychloroquine for long-standing rheumatoid arthritis, having previously received methotrexate and sulfasalazine...Some cases described in the literature as APL in irradiated areas are possibly the lymphatic subtype of an AVL. As there was no latency between irradiation and onset, our case is more likely APL, rather than AVL outside the field of irradiation.

A diagnosis of sarcoid dactylitis was made and treatment commenced with a reducing course of prednisolone 40 mg daily, along with hydroxychloroquine 200 mg twice daily...The radiological findings can therefore aid diagnosis. Our case highlights the rare initial presentation of dactylitis as a manifestation of paraneoplastic sarcoid.

A 36-year-old woman with recurrent aphthous stomatitis had not responded to treatment with colchicine, pentoxifylline, azathioprine, dapsone or mycophenolate mofetil...A 49-year-old woman with severe recalcitrant cutaneous discoid lupus erythematosus (CDLE), systemic lupus and Raynaud phenomenon with chilblains had not responded to, had intolerance to or had adverse side-effects with multiple systemic agents including hydroxychloroquine, mepacrine, dapsone, rituximab biosimilar, mycophenolate mofetil, fumaric acid esters, acitretin, ciclosporin, thalidomide (tremor/loss of concentration), belimumab and methotrexate...Baseline and renal function monitoring is required for dose adjustment, and strict adherence to pregnancy prevention programmes is necessitated due to teratogenicity. Our three cases demonstrate lenalidomide to be a clinically beneficial, fast-acting and well-tolerated alternative off-label option for recalcitrant inflammatory dermatoses.

P3, N=210, Recruiting, National Taiwan University Hospital

Furthermore, inhibiting the late stage of autophagy with hydroxychloroquine (HCQ) decreased cell viability, while early-stage autophagy inhibition using 3-Methyladenine (3-MA) had no significant effect. These results highlight the critical role of Nrf2 in controlling foam cell development, senescence, and autophagic processes, giving valuable insights into potential therapeutic targets for atherosclerosis.

Chloroquine (CQ) and hydroxychloroquine (HCQ) have shown potential owing to their roles in autophagy modulation and immune regulation. Gene expression profiling and flow-cytometry analyses revealed cell-type-specific differences in apoptosis, mitochondrial potential, and DNA damage, suggesting HCQ's selective anti-tumor potential in gingival carcinoma. These findings highlight HCQ as a repurposed adjuvant therapy that modulates autophagy and apoptosis to enhance chemosensitivity in oral cancer.

The condition remained poorly controlled despite administration of Prednisone combined with Hydroxychloroquine, and showed no significant improvement after adding methotrexate. reported here findings suggest that T-DXd may trigger multi-system involvement through immune-mediated mechanisms, resulting in drug-induced dermatomyositis and interstitial pneumonia. Our findings highlight the need for heightened vigilance regarding such immune-related adverse events during T-DXd therapy, where early recognition and intervention are critically important to avoid irreversible and possibly fatal complications.

P4, N=1000, Active, not recruiting, Liverpool School of Tropical Medicine | Recruiting --> Active, not recruiting

P4, N=50, Not yet recruiting, Radboud University Medical Center

These data support a significant role for a type II IFN-associated immune response in SjD pathogenesis, which is targeted by LEF/HCQ. Proteins associated with type II IFN-driven immune responses hold potential to monitor disease activity and predict treatment response.

TRE, either alone or combined with siRNA, showed limited efficacy and may counteract the apoptotic benefits of HCQ. Conversely, HCQ, whether used alone or in combination with siRNA, enhanced apoptosis, suggesting promise as a potential treatment for melanoma.