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    BIOMARKER:

    HUWE1 mutation

    i
    Other names: HUWE1, HECT UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1, Homologous To E6AP Carboxyl Terminus Homologous Protein 9, Upstream Regulatory Element-Binding Protein 1, HECT-Type E3 Ubiquitin Transferase HUWE1, E3 Ubiquitin-Protein Ligase HUWE1, Mcl-1 Ubiquitin Ligase E3, Large Structure Of UREB1, ARF-Binding Protein 1, URE-Binding Protein 1, ARF-BP1, URE-B1, LASU1, UREB1, HECT, UBA And WWE Domain Containing 1 E3 Ubiquitin Protein Ligase, HECT, UBA And WWE Domain-Containing Protein 1,
    Entrez ID:
    10075
    3years
    Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients. (PubMed, Gene)
    Relative to Caucasian non-responders to endocrine therapy, B/AA non-responders show suppressed expression of a signature gene set on which biological processes including signaling by interleukins, circadian clock, regulation of lipid metabolism by PPARα, FOXO-mediated transcription, and regulation of TP53 degradation are over-represented. Thus, we identify molecular expression patterns suggesting diminished response to oxidative stress, changes in regulation of tumor suppressors/facilitators, and enhanced immortalization in B/AA patients are likely important in defining the more aggressive molecular tumor phenotype reported in B/AA patients.
    Clinical • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • TERT (Telomerase Reverse Transcriptase) • MIR221 (MicroRNA 221) • HUWE1 (HECT UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1) • MIR135B (MicroRNA 135b) • E2F1 (E2F transcription factor 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha)
    |
    TP53 mutation • PIK3CA mutation • PTEN mutation • MYC expression • PTEN expression • HUWE1 mutation • miR-135-b expression
    over4years
    Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma. (PubMed, Gynecol Oncol)
    Downregulation/inactivation of HUWE1 may increase c-MYC expression and proliferation in primary-CC-cell-lines. GS-626510 may represent a novel, potentially highly effective therapeutic agent against CC overexpressing c-MYC and/or harboring HUWE1 mutations. Clinical studies with BET inhibitor in CC-patients harboring radiation/chemotherapy-resistant disease are warranted.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • HUWE1 (HECT UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1)
    |
    MYC amplification • MYC overexpression • MYC expression • HUWE1 mutation
    |
    GS-626510
    over4years
    Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients. (PubMed, Gene X)
    Relative to Caucasian non-responders to endocrine therapy, B/AA non-responders show suppressed expression of a signature gene set on which biological processes including signaling by interleukins, circadian clock, regulation of lipid metabolism by PPARα, FOXO-mediated transcription, and regulation of TP53 degradation are over-represented. Thus, we identify molecular expression patterns suggesting diminished response to oxidative stress, changes in regulation of tumor suppressors/facilitators, and enhanced immortalization in B/AA patients are likely important in defining the more aggressive molecular tumor phenotype reported in B/AA patients.
    Clinical • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • MIR221 (MicroRNA 221) • HUWE1 (HECT UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1) • MIR135B (MicroRNA 135b) • E2F1 (E2F transcription factor 1)
    |
    TP53 mutation • PIK3CA mutation • PTEN mutation • MYC expression • PTEN expression • HUWE1 mutation • miR-135-b expression