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    GENE:

    HUS1 (HUS1 Checkpoint Clamp Component)

    i
    Other names: HUS1, HUS1 Checkpoint Clamp Component, Checkpoint Protein HUS1, Hus1+-Like Protein, HHUS1, HUS1 (S. Pombe) Checkpoint Homolog, HUS1 Checkpoint Homolog (S. Pombe), HUS1 Checkpoint Homolog
    Associations

    News

    Trials
    over3years
    A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells. (PubMed, Metallomics)
    In the current study we demonstrate that an organometallic nucleoside analogue, the ferronucleoside 1-(S,Rp), is cytotoxic in a panel of PDAC cell lines including gemcitabine-resistant MIAPaCa2, with IC50 values comparable to cisplatin. Studies in p53 deficient cell lines showed activation of CDKN1A (p21) and GADD45A by 1-(S, Rp) was at least partially independent of p53. In conclusion, because of its potency and activity in gemcitabine resistant cells, 1-(S, Rp) is a promising candidate molecule for development of new treatments for PDAC.
    Journal
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    MRE11A (MRE11 homolog, double strand break repair nuclease) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • ERCC4 (ERCC Excision Repair 4, Endonuclease Catalytic Subunit) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • RPA1 (Replication Protein A1) • HUS1 (HUS1 Checkpoint Clamp Component)
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    cisplatin • gemcitabine