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    GENE:

    HSPB8 (Heat Shock Protein Family B (Small) Member 8)

    i
    Other names: HSPB8, Heat Shock Protein Family B (Small) Member 8, E2IG1, HSP22, CMT2L, H11, Small Stress Protein-Like Protein HSP22, Heat Shock 27kDa Protein 8, Heat Shock 22kDa Protein 8, Heat Shock Protein Beta-8, E2-Induced Gene 1 Protein, Alpha-Crystallin C Chain, Protein Kinase H11, DHMN2, HMN2A, CRYAC, HspB8, HMN2
    Associations

    News

    Trials
    2ms
    Identification of ACE and HSPB8 as novel drug targets for LUSC treatment and prognosis based on a prognostic model integrating epigenetic regulation and endoplasmic reticulum stress-related genes. (PubMed, PLoS One)
    This comprehensive bioinformatics and experimental study highlights ACE and HSPB8 as novel targets for LUSC treatment and prognosis, emphasizing their roles in epigenetic regulation and ERS. The risk model demonstrates preliminary potential for guiding personalized therapeutic strategies, emphasizing the need for a deeper understanding of epigenetic mechanisms and ERS in cancer development and treatment. Thus, our findings open avenues for further research into targeted therapies for LUSC, aiming to improve patient outcomes through precision medicine that considers both epigenetic factors and ERS.
    Journal • IO biomarker
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    HSPB8 (Heat Shock Protein Family B (Small) Member 8)
    4ms
    Recognition of HSPB8 as a potential therapeutic target for prostate cancer. (PubMed, Front Genet)
    Its tumor-suppressive function was likely mediated through inactivation of PI3K-AKT signaling. Overall, this study offers a new understanding into the pathogenesis of prostate cancer, proposing that targeting HSPB8 might be a promising area in prostate cancer treatment.
    Journal
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    HSPB8 (Heat Shock Protein Family B (Small) Member 8)
    4ms
    Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA. (PubMed, Autophagy)
    Indeed, acetylation of MUT TP53 increases its interaction with STUB1 (STIP1 homology and U-box containing protein 1), HSPB8 (heat shock protein family B (small) member 8) and HSPA8 (heat shock protein family A (Hsp70) member 8) and the latter, itself acetylated by VPA, binds to BAG3 (BAG cochaperone 3), facilitating the recruitment of MUT TP53 into the CASA pathway. These findings elucidate the mechanisms through which acetylation leads to the selective lysosomal clearance of MUT TP53, highlighting a potential therapeutic vulnerability of aggressive tumors expressing this oncoprotein.
    Journal
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    TP53 (Tumor protein P53) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
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    TP53 mutation
    5ms
    Multi-Omics Integrated Analysis of the Protective Effect of Tertiary Lymphoid Structures and Associated Key Regulatory Genes in Human Gallbladder Cancer. (PubMed, J Gene Med)
    In conclusion, TLS had a protective effect on human GBC, and its related genes, played a potential role in diagnosis, prognosis, immune infiltration, and metastasis of GBC. Our findings provided a new insight for the research on clinical biomarkers of GBC and development of its therapeutic targets.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • CCNB1 (Cyclin B1) • FLNC (Filamin C) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • MYLK (Myosin Light Chain Kinase)
    over1year
    Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications. (PubMed, Neural Regen Res)
    This is the case of cognitive impairment related to diabetes mellitus, in which HSPB8 exerts a protective activity by assuring mitochondrial homeostasis.This review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions, focusing on the beneficial effects of its modulation. Drug-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed, emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.
    Journal
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    HSPB8 (Heat Shock Protein Family B (Small) Member 8)
    over1year
    HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation. (PubMed, Cancer Biol Ther)
    Overexpression of HSPB8 and BAG3 in vivo promoted the lung metastasis ability of ICC cells. The HSPB8-BAG3 chaperone complex promotes ICC cell migration and invasion by regulating CASA-mediated degradation of Filamin A, offering insights for enhancing ICC therapeutic strategies.
    Journal
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    FLNA (Filamin A) • HSPB8 (Heat Shock Protein Family B (Small) Member 8)
    over1year
    Molecular insights into programmed cell death in esophageal squamous cell carcinoma. (PubMed, PeerJ)
    Notably, INHBA knockdown suppressed ECSS cell migration and invasion and altered the expression of important apoptotic and survival proteins. This study identified significant molecules with promising accuracy for the diagnosis of ESCC, which may provide a new perspective and experimental basis for ESCC research.
    Journal
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    HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • LRRK2 (Leucine Rich Repeat Kinase 2)
    over1year
    Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy. (PubMed, J Zhejiang Univ Sci B)
    Notably, the overexpression of HSPB8 partially restored the reduced autophagy levels caused by silencing ST3GAL6 expression. Our results indicate that ST3GAL6 regulates autophagy through the HSPB8-BAG3 complex.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • BECN1 (Beclin 1) • HSPB8 (Heat Shock Protein Family B (Small) Member 8)
    over1year
    Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer. (PubMed, Iran J Basic Med Sci)
    Furthermore, MAPK3 was positively correlated with LGALS9, and negatively correlated with CTLA4 and CD40. Our results show that MAPK3 can be used as a new prognostic biomarker to predict the prognosis of patients with CC.
    Journal • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • BIRC5 (Baculoviral IAP repeat containing 5) • CCL2 (Chemokine (C-C motif) ligand 2) • CD40 (CD40 Molecule) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) • TNFSF10 (TNF Superfamily Member 10) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • ITGB4 (Integrin Subunit Beta 4) • LGALS9 (Galectin 9) • MAPK3 (Mitogen-Activated Protein Kinase 3) • PTK6 (Protein Tyrosine Kinase 6) • SPHK1 (Sphingosine Kinase 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    over1year
    Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer. (PubMed, Iran J Basic Med Sci)
    Furthermore, MAPK3 was positively correlated with LGALS9, and negatively correlated with CTLA4 and CD40. Our results show that MAPK3 can be used as a new prognostic biomarker to predict the prognosis of patients with CC.
    Journal • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • BIRC5 (Baculoviral IAP repeat containing 5) • CCL2 (Chemokine (C-C motif) ligand 2) • CD40 (CD40 Molecule) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) • TNFSF10 (TNF Superfamily Member 10) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • ITGB4 (Integrin Subunit Beta 4) • LGALS9 (Galectin 9) • MAPK3 (Mitogen-Activated Protein Kinase 3) • PTK6 (Protein Tyrosine Kinase 6) • SPHK1 (Sphingosine Kinase 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    almost2years
    Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy. (PubMed, J Zhejiang Univ Sci B)
    Notably, the overexpression of HSPB8 partially restored the reduced autophagy levels caused by silencing ST3GAL6 expression. Our results indicate that ST3GAL6 regulates autophagy through the HSPB8-BAG3 complex.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAG1 (BAG Cochaperone 1) • BECN1 (Beclin 1) • HSPB8 (Heat Shock Protein Family B (Small) Member 8)