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    GENE:

    HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)

    i
    Other names: HSPA8, Heat Shock Protein Family A (Hsp70) Member 8, HSC70, HSP73, HSPA10, HSC71, Lipopolysaccharide-Associated Protein 1, Heat Shock Cognate 71 KDa Protein, Heat Shock 70kDa Protein 8, LPS-Associated Protein 1, LAP-1, Epididymis Secretory Sperm Binding Protein Li 72p, N-Myristoyltransferase Inhibitor Protein 71, Constitutive Heat Shock Protein 70, Epididymis Luminal Protein 33, Heat Shock Cognate Protein 54, Heat Shock 70 KDa Protein 8, Heat Shock 70kd Protein 10, Heat Shock 70kD Protein 8, HEL-S-72p, HEL-33, HSC54, HSP71, NIP71, LAP1
    Associations

    News

    Trials
    2d
    Utilizing bulk and single-cell RNA sequencing to identify potential biomarkers linked to angiogenesis and integrated stress response in chondrosarcoma. (PubMed, Sci Rep)
    Moreover, 9 transcription factors (TFs) (like STAT1), 69 key microRNAs (miRNAs) (like hsa-miR-361-3p), and 78 long non-coding RNAs (lncRNAs) (like NEAT1) were found to have relationships with potential biomarkers, and potential biomarkers had stable binding affinity with adenosine diphosphate (ADP) and lonafarnib...Importantly, RT-qPCR confirmed higher expression of HSPA8, LMNA and SERPINH1 in CS patients. The findings suggested that HSPA8, LMNA and SERPINH1 might offer novel insights for the development of targeted therapies for CS associated with angiogenesis and ISR.
    Journal
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    SERPINH1 (Serpin family H member 1) • LMNA (Lamin A/C) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • MIR361 (MicroRNA 361) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    2ms
    PERP suppresses breast cancer metastasis via the ATF3-HSPA6 signaling pathway. (PubMed, J Int Med Res)
    Knockdown of ATF3 or HSPA6 eliminated the antimetastatic effects of PERP.ConclusionsPERP suppresses breast cancer metastasis by inducing ATF3, which in turn activates HSPA6 transcription. This PERP-ATF3-HSPA6 axis represents a key regulatory pathway and serves as a potential therapeutic target in metastatic breast cancer.
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    HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) • ATF3 (Activating Transcription Factor 3) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    2ms
    HSPA8 promotes the progression of gastric cancer by activating the canonical Wnt pathway and glycolysis. (PubMed, Hum Cell)
    The results of the current study validated the oncogenic function of HSPA8 in GC. Its overexpression is linked to GC development and poor clinicopathology.
    Journal
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    HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    2ms
    Integration of Single-cell and Bulk Transcriptome Analyses Unravels a Macrophage-based Gene Signature for Prognostication and Treatment in Triple-negative Breast Cancer. (PubMed, Int J Med Sci)
    The aberrant expression of these signature genes contributes to tumor malignant progression. Our findings offer valuable insights for future clinical research involving macrophages in TNBC.
    Journal • Gene Signature • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • CTSD (Cathepsin D) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    2ms
    Microbial metabolite trimethylamine-N-oxide facilitates colorectal inflammation-cancer transformation by blocking lysosomal degradation of Wnt signaling. (PubMed, Gut Microbes)
    Further mechanistic studies revealed that TMAO interacted with heat shock protein family A member 8 (Hspa8, also known as Hsc70), a molecular chaperone that mediates autophagy, to block the lysosomal degradation of the β-catenin protein, leading to an increase in the downstream targets cyclin D1 and c-Myc, thus contributing to colorectal carcinogenesis. Our results indicated that TMAO serves as a bridge to establish the connection between microbiota and colorectal carcinogenesis, playing a critical pathogenic role during CRC progression and therefore provides novel mechanistic insights into the intestinal inflammation in colorectal neoplasia progression.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    3ms
    Circular RNA DENND4C Regulates Cell Malignant Behaviors in Breast Cancer Through the miR-26a-5p/HSPA8 Axis. (PubMed, Breast Cancer (Dove Med Press))
    circDENND4C mediated HSPA8 expression by competitively adsorbing miR-26a-5p. circDENND4C absorbs miR-26a-5p to target HSPA8, thereby promoting BC progression, which provides a new insight into the mechanism of BC.
    Journal
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    MIR26A1 (MicroRNA 26a-1) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    3ms
    Molecular Resonance Quantification and Label-Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab. (PubMed, Cancer Med)
    Combination of PIMS and NPOT coupled to label-free quantitative proteomics point towards the distinct panitumumab mode of action in CRC patients and highlights specific proteins as prognostic biomarkers which need further validation in a bigger cohort and multicentric investigation, ideally involving patient registry follow up data.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • POLD1 (DNA Polymerase Delta 1) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • ENO1 (Enolase 1) • YBX1 (Y-Box Binding Protein 1) • CTNND1 (Catenin Delta 1) • ITGB2 (Integrin Subunit Beta 2) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • NT5C (5', 3'-Nucleotidase, Cytosolic) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • ITGB1 (Integrin Subunit Beta 1) • PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • NCAPD2 (Non-SMC Condensin I Complex Subunit D2)
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    Vectibix (panitumumab)
    3ms
    Novel HSPA8-NR4A2 rearrangement in extraskeletal myxoid chondrosarcoma: a sarcoma mimicker of neuroendocrine neoplasia. (PubMed, Virchows Arch)
    Transcriptome cluster comparative analysis placed its expression profile close to pancreas neuroendocrine tumors. This case suggests NR4A2 as a functionally substitute for NR4A3 in tumorigenesis and a neuroendocrine lineage differentiation for a subset of EMC.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • NR4A3 (Nuclear receptor subfamily 4 group A member 3) • NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
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    TMB-L
    3ms
    Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy. (PubMed, Autophagy Rep)
    These findings identify SIRT2-mediated deacetylation of HSC70 as a regulatory mechanism for CMA activation during nutrient deprivation and highlight the role of protein lysine acetylation in proteostasis. This study provides insights into the interplay between SIRT2, HSC70, and CMA, with potential implications for diseases linked to proteostasis dysregulation, including neurodegenerative disorders and cancer.
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    HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)