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    BIOMARKER:

    HSPA6 expression

    i
    Other names: HSPA6, Heat Shock Protein Family A (Hsp70) Member 6, HSP70B, Heat Shock 70kDa Protein 6 (HSP70B’), Heat Shock 70kD Protein 6 (HSP70B’), Heat Shock 70 KDa Protein B, Heat Shock 70 KDa Protein 6, Epididymis Secretory Sperm Binding Protein
    Entrez ID:
    3310
    9ms
    Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes. (PubMed, J Immunol Res)
    Furthermore, the augmentation of the antitumor effects of CD16-independent NK cells upon pretreatment with Elo enhanced the expression of CRTAM, TNFRSF9, EAT-2, and FOXP3 genes and reduced the expression of HSPA6. Our results suggest that Elo directly promotes the cytotoxic function of CD16-independent NK cells against target cells, which is associated with the upregulation of the expression of several NK cell-enhancing genes.
    Journal • IO biomarker
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    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF9 (TNF Receptor Superfamily Member 9) • LAMP1 (Lysosomal Associated Membrane Protein 1) • GZMB (Granzyme B) • FOXP3 (Forkhead Box P3) • CRTAM (Cytotoxic And Regulatory T Cell Molecule) • HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) • SLAMF7 (SLAM Family Member 7)
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    HSPA6 expression • FOXP3 expression
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    Empliciti (elotuzumab)
    1year
    Lactate-lactylation-HSPA6 axis promotes PRRSV replication by impairing IFN-β production. (PubMed, J Virol)
    We also dissected the mechanism by which HSPA6 negatively regulates IFN-β production. To our knowledge, this is the first report to study virus-induced lactylation and establish the relationship between lactylation and virus infection.
    Journal
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    HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) • IFNB1 (Interferon Beta 1)
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    HSPA6 expression
    1year
    PP4R1 accelerates the malignant progression of NSCLC via up-regulating HSPA6 expression and HSPA6-mediated ER stress. (PubMed, Biochim Biophys Acta Mol Cell Res)
    More importantly, the overexpression of HSPA6 resulted in the same malignant progression of NSCLC as PP4R1 overexpression, and both concomitant with the activation of endoplasmic reticulum (ER) stress. In aggregate, PP4R1 contributed to the malignant progression of NSCLC via up-regulating HSPA6 expression and then activating ER stress.
    Journal
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    HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6)
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    HSPA6 expression
    over1year
    RNA sequencing reveals the transcriptomic landscape and alternative splicing events induced by LGALS1 silencing in non-small cell lung cancer. (PubMed, Adv Clin Exp Med)
    We characterized the transcriptomic landscape and profiled AS events in A549 cells following LGALS1 silencing. Our study provides abundant candidate markers and new insights into NSCLC.
    Journal
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    LGALS1 (Galectin 1) • HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6)
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    HSPA6 expression
    almost2years
    BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression. (PubMed, J Orthop Surg Res)
    In conclusion, BARX1 promotes OS cell proliferation and migration by inducing the expression of HSPA6, which plays an oncogenic role in OS. BARX1 and HSPA6 can potentially act as novel therapeutic targets for OS.
    Journal
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    HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6)
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    HSPA6 expression
    2years
    HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer. (PubMed, J Clin Lab Anal)
    HSPA6 promotes GC proliferation by the Hippo pathway, as a novel prognostic biomarker and potential therapeutic target.
    Journal
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    HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) • CCNB1 (Cyclin B1)
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    HSPA6 expression