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    GENE:

    HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)

    i
    Other names: HSPA4, Heat Shock Protein Family A (Hsp70) Member 4, HS24/P52, HSPH2, Heat Shock 70-Related Protein APG-2, Heat Shock 70 KDa Protein 4, Heat Shock 70kD Protein 4, Hsp70 RY, Epididymis Secretory Sperm Binding Protein Li 5a, Heat Shock Protein, 110 KDa, Heat Shock 70kDa Protein 4, HEL-S-5a, Hsp70RY, HSP70RY, APG-2, Hsp70, APG2, RY
    Associations

    News

    Trials
    2ms
    Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic Perspective. (PubMed, In Vivo)
    FTO participates in the regulation of the cellular stress response and the ubiquitin-dependent ERAD pathway, functions potentially independent of its demethylase activity. Importantly, dysregulation of these pathways has been implicated in cancer initiation, progression, and therapeutic resistance. Therefore, our findings provide new insights into how FTO mutations might influence oncogenic processes, highlighting FTO as a potential biomarker and therapeutic target in cancer biology.
    Journal
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    PCNA (Proliferating cell nuclear antigen) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)
    3ms
    Molecular Resonance Quantification and Label-Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab. (PubMed, Cancer Med)
    Combination of PIMS and NPOT coupled to label-free quantitative proteomics point towards the distinct panitumumab mode of action in CRC patients and highlights specific proteins as prognostic biomarkers which need further validation in a bigger cohort and multicentric investigation, ideally involving patient registry follow up data.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • POLD1 (DNA Polymerase Delta 1) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • ENO1 (Enolase 1) • YBX1 (Y-Box Binding Protein 1) • CTNND1 (Catenin Delta 1) • ITGB2 (Integrin Subunit Beta 2) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • NT5C (5', 3'-Nucleotidase, Cytosolic) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • ITGB1 (Integrin Subunit Beta 1) • PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • NCAPD2 (Non-SMC Condensin I Complex Subunit D2)
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    Vectibix (panitumumab)
    4ms
    Molecular mechanisms of lung cancer induced by the insecticide lambda-cyhalothrin (PubMed, Sheng Wu Gong Cheng Xue Bao)
    Molecular docking demonstrated spontaneous binding of LCT to core targets mediated by hydrogen bonds and π-cation interactions. These results establish a theoretical framework for evaluating LCT-associated risks of lung cancer and respiratory system damage.
    Journal
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    EGFR (Epidermal growth factor receptor) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CCL2 (Chemokine (C-C motif) ligand 2) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)
    4ms
    Activating transcription factor 4-mediated upregulation of Heat Shock Protein Family A Member 4 promotes hepatocellular carcinoma progression through activation of Wnt/β-catenin/EMT signaling pathway. (PubMed, Int J Biol Macromol)
    Knockdown of ATF4 reduced HSPA4 levels and suppressed HCC progression. These findings suggest that HSPA4, regulated by ATF4, may serve as a promising therapeutic target and prognostic biomarker for HCC.
    Journal • IO biomarker
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    FLT3 (Fms-related tyrosine kinase 3) • BCL2 (B-cell CLL/lymphoma 2) • ATRX (ATRX Chromatin Remodeler) • SQSTM1 (Sequestosome 1) • DNMT1 (DNA methyltransferase 1) • ATF4 (Activating Transcription Factor 4) • GATA3 (GATA binding protein 3) • RNF31 (Ring Finger Protein 31) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • MAPK8 (Mitogen-activated protein kinase 8) • TCF4 (Transcription Factor 4) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    4ms
    Activation of CDKN2A and Up-regulation of PETN Are Key Features of Sunscreen Usage Versus Light Irradiation. (PubMed, J Lasers Med Sci)
    ERBB2, SMAD3, and PRKACA were pointed out as the skin cancer-related genes. In conclusion, the up-regulation of PETN and the activation of CDKN2A were highlighted as the major induced molecular events by sunscreen, which play a role in skin protection.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • PTEN (Phosphatase and tensin homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CD31 (Platelet and endothelial cell adhesion molecule 1) • CDC42 (Cell Division Cycle 42) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • SMAD3 (SMAD Family Member 3)
    7ms
    Five autoantibodies identified from immune complexes as breast cancer biomarkers. (PubMed, Front Immunol)
    The autoantibodies identified from ICs can serve as effective serum biomarkers for breast cancer. Anti-HSPA4, anti-PRPF19, anti-ENO1, anti-PRDX6, and anti-MMP14 autoantibodies showed significant increases in breast cancer patients.
    Journal
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    ENO1 (Enolase 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • MMP14 (Matrix Metallopeptidase 14) • SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) • VDAC1 (Voltage Dependent Anion Channel 1)
    8ms
    Exploring the role of PANoptosis related genes in the prognosis of oral squamous cell carcinoma subtypes based on multi-omics analysis. (PubMed, Discov Oncol)
    Two OSCC subtypes and eight prognostic genes (TGFBR3, CYCS, HDAC9, PLK1, GSDMB, HSPA4, BAK1, SOD2) were identified, aiding in treatment and risk stratification. BAK1 is causally linked to OSCC risk.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • PLK1 (Polo Like Kinase 1) • BAK1 (BCL2 Antagonist/Killer 1) • HDAC9 (Histone Deacetylase 9) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • SOD2 (Superoxide Dismutase 2)
    8ms
    Machine learning assists regulated cell death crucial biomarker selection in adenocarcinoma of the lung: biological data testing and cell assay determination. (PubMed, Discov Oncol)
    Prognostic PCD-related genes for lung cancer were identified and a prognostic signature was constructed. Our findings are invaluable for lung cancer prognostic prediction and personalized treatment.
    Journal
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    ALK (Anaplastic lymphoma kinase) • ACSL3 (Acyl-CoA Synthetase Long Chain Family Member 3) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)
    8ms
    Redistribution of super-enhancers promotes malignancy in human hepatocellular carcinoma. (PubMed, J Adv Res)
    The dysregulated SE landscape of HCC promoted the malignancy phenotype by the upregulation of oncogenes, and SE-regulatory network might be potential drug targets for HCC treatment. Our study deepened the insight of epigenetic dysregulation in HCC, offering the groundwork for SEs as potential therapeutic targets of HCC treatment.
    Journal
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    BRD4 (Bromodomain Containing 4) • PDGFA (Platelet Derived Growth Factor Subunit A) • CDKN2C (Cyclin Dependent Kinase Inhibitor 2C) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)
    8ms
    Clinical significance and immune microenvironment association of cuproptosis-related genes in pan-cancer. (PubMed, Exp Physiol)
    Fluorescence images of colon cancer from different patients demonstrated a positive correlation between CDKN2A expression and the number of CD45+ immune cells. Our research has provided a comprehensive understanding of cuproptosis regulators and revealed potential prognostic biomarkers and therapeutic targets for cancers.
    Journal • Pan tumor
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • DLAT (Dihydrolipoamide S-Acetyltransferase) • MELTF (Melanotransferrin) • FDX1 (Ferredoxin 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • LIAS (Lipoic Acid Synthetase) • LIPT1 (Lipoyltransferase 1) • PDHA1 (Pyruvate Dehydrogenase E1 Subunit Alpha 1) • SLC31A1 (Solute Carrier Family 31 Member 1)
    11ms
    3' untranslated region somatic variants connect alternative polyadenylation dysregulation in human cancers. (PubMed, J Genet Genomics)
    Finally, we establish that SNV-related abnormal APA usage serves as an additional layer of expression regulation for tumor-suppressor gene HMGN2 in breast cancer. Collectively, this study reveals 3' UTR APA as a critical mechanism mediating the functional impact of somatic noncoding variants in human cancers.
    Journal
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    HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)
    11ms
    LINC01004/hsa-mir-125b-2-3p axis restrains ferroptosis in hepatocellular carcinoma by targeting HSPA4 via ceRNA mechanism. (PubMed, Technol Health Care)
    Si-HSPA4 related ferroptosis was generated through impairing iron transport via targeting restrain GPX4. For human subjects, the RT-qPCR analysis revealed the that the larger the tumor diameter, the higher the LINC01004, HSPA4, and GPX4 expression, and the lower the hsa-miR-125b-2-3p expression.ConclusionLINC01004/hsa-miR-125b-2-3p/HSPA4 regulatory axis involved in the ferroptosis of the progression of HCC via GPX4 dependent method, providing new therapeutic targets for HCC patients.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4)