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    BIOMARKER:

    HRD Signature-3

    i
    Other names: HRD, Homologous Recombination Deficiency
    Related biomarkers:
    Others
    over2years
    Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a poly (adenosine diphosphate [ADP]- ribose) polymerase (PARP) inhibitor. (PubMed, Gynecol Oncol)
    OCS and UCS cell lines harboring HRD signature-3 were significantly more sensitive to olaparib in vitro and in vivo when compared to HRP CS. Clinical studies with PARPi in CS patients with a dominant signature 3 (HRD-related) are warranted.
    Preclinical • Journal
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    HRD (Homologous Recombination Deficiency)
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    HRD • HRD Signature-3
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    Lynparza (olaparib)