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DRUG:

HPN601

i
Other names: HPN601, EpCAM ProTriTAC
Associations
Trials
Company:
Merck (MSD)
Drug class:
EPCAM inhibitor
Associations
Trials
4years
Clinical
|
EPCAM (Epithelial cell adhesion molecule)
|
HPN601
4years
[VIRTUAL] HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors (SITC 2020)
For example, clinical testing of solitomab, an EpCAM-targeting T cell engager, resulted in severe dose-limiting toxicities, including elevated liver transaminases, hyperbilirubinemia, and diarrhea. Conclusions HPN601 is a conditionally active EpCAM-targeting T cell engager with a ten-fold improved therapeutic window compared to a constitutively active EpCAM-targeting T cell engager. An EpCAM-specific T cell engager with an improved safety profile could address unmet needs in many solid tumors and demonstrate the feasibility of using conditionally active T cell engagers to target more solid tumor antigens.
Clinical
|
IFNG (Interferon, gamma) • IL6 (Interleukin 6) • IL2 (Interleukin 2) • EPCAM (Epithelial cell adhesion molecule) • IL10 (Interleukin 10)
|
EPCAM expression
|
HPN601 • solitomab (AMG 110)
4years
[VIRTUAL] HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors (SITC 2020)
For example, clinical testing of solitomab, an EpCAM-targeting T cell engager, resulted in severe dose-limiting toxicities, including elevated liver transaminases, hyperbilirubinemia, and diarrhea. Conclusions HPN601 is a conditionally active EpCAM-targeting T cell engager with a ten-fold improved therapeutic window compared to a constitutively active EpCAM-targeting T cell engager. An EpCAM-specific T cell engager with an improved safety profile could address unmet needs in many solid tumors and demonstrate the feasibility of using conditionally active T cell engagers to target more solid tumor antigens.
Clinical
|
IFNG (Interferon, gamma) • IL6 (Interleukin 6) • IL2 (Interleukin 2) • EPCAM (Epithelial cell adhesion molecule) • IL10 (Interleukin 10)
|
EPCAM expression
|
HPN601 • solitomab (AMG 110)