^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    HOXC8 overexpression

    i
    Other names: HOXC8, Homeobox C8, Homeobox Protein Hox-C8, Homeobox Protein Hox-3A, Homeo Box C8, HOX3A, Hox-3.1 Mouse Homolog Of, Homeo Box 3A, HOX3
    Entrez ID:
    3224
    almost2years
    DNA Methylation-Regulated HOXC8's Role in HER2-Positive Breast Cancer Function and its Contribution to Herceptin Resistance. (PubMed, Discov Med)
    In HER2-positive breast cancer, the expression of HOXC8 is elevated in a manner dependent on DNA methylation, and this elevated expression is closely linked to the pathology of the patient. Interfering with HOXC8 expression demonstrates the potential to partially inhibit the development and spread of breast cancer, as well as to alleviate resistance to Herceptin.
    Journal • Epigenetic controller
    |
    HER-2 (Human epidermal growth factor receptor 2) • HOXC8 (Homeobox C8)
    |
    HER-2 positive • HER-2 overexpression • HOXC8 overexpression
    |
    Herceptin (trastuzumab)
    over2years
    Comprehensive analysis of HOXC8 associated with tumor microenvironment characteristics in colorectal cancer. (PubMed, Heliyon)
    HOXC8 overexpression was associated with poor prognosis and specific TME subtypes in CRC. This study provided valuable resource for further exploring the potential mechanisms and therapeutic targets of HOX genes in CRC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    TMB (Tumor Mutational Burden) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HOXC8 (Homeobox C8)
    |
    PD-L1 expression • TMB-H • CTLA4 expression • HOXC8 overexpression • PD-L1 expression + CTLA4 expression
    over2years
    Long intergenic non-protein-coding RNA 1547 acts as a competing endogenous RNA and exerts cancer-promoting activity in non-small cell lung cancer by targeting the microRNA-195-5p/ homeobox C8 axis. (PubMed, Heliyon)
    Conclusively, LINC01547 serves as a crucial component to worsen the oncogenicity of NSCLC cells by controlling the miR-195-5p/HOXC8 axis. Thus, the newly identified competing endogenous RNA pathway may potentially be an attractive therapeutic for NSCLC management.
    Journal
    |
    HOXC8 (Homeobox C8) • MIR195 (MicroRNA 195)
    |
    HOXC8 overexpression
    over5years
    Downregulation of circNRIP1 Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-211-5p/HOXC8 Axis. (PubMed, Cancer Manag Res)
    Additionally, the expression of HOXC8 was regulated by circNRIP1 and miR-211-5p. CircNRIP1 silencing could inhibit the PTX resistance of OC via regulating the miR-211-5p/HOXC8 axis, showing that circNRIP1 might be a potential target for OC resistance treatment.
    Journal
    |
    MIR211 (MicroRNA 211) • HOXC8 (Homeobox C8)
    |
    HOXC8 overexpression
    |
    paclitaxel