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    GENE:

    HOXB2 (Homeobox B2)

    i
    Other names: Homeobox B2, Homeobox Protein Hox-2.8, Homeobox Protein Hox-B2, Homeobox Protein Hox-2H, Homeo Box B2, HOX2H, K8, K8 Home Protein, Homeo Box 2H, Hox-2.8, HOXB2, HOX2
    Associations

    News

    Trials
    8ms
    CircRAPGEF5 Promotes LUAD by Mediating the HOXC6 Stability. (PubMed, FASEB J)
    Collectively, our findings indicated that circRAPGEF5 facilitates LUAD progression and metastasis by stabilizing HOXC6 mRNA via HNRNPC and promoting HOXB2 transcription. These results suggest that targeting circRAPGEF5 and HOXC6 can be a promising approach for LUAD treatment.
    Journal
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    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) • HOXB2 (Homeobox B2) • HOXC6 (Homeobox C6)
    11ms
    HOXB and HOXD genes contribute to the carcinogenic processes in glioblastoma: evidence form a bioinformatics analysis. (PubMed, Cancer Treat Res Commun)
    Taken together, we showed contribution of HOXB and HOXD genes in the carcinogenic processes and proposed them as possible targets for treatment options.
    Journal
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    HOXD8 (Homeobox D8) • HOXB2 (Homeobox B2)
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    lapatinib • methotrexate
    1year
    Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival. (PubMed, Cell Death Differ)
    Specifically, depletion of HOXA2 leaded to a concomitantly decreased expression of PPARγ and its target CIDEC, a master regulator of lipid droplet (LD) accumulation, thereby resulting in reduced LD abundance in BC cells. In summary, our study identifies HOXA2 as a novel prognosis-relevant tumor suppressor in the mammary gland.
    Journal
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    PPARG (Peroxisome Proliferator Activated Receptor Gamma) • HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2)
    1year
    HOXA7 Expression Is an Independent Prognostic Biomarker in Esophageal Squamous Cell Carcinoma. (PubMed, Genes (Basel))
    This finding opens new possibilities for targeted therapies, offering hope for improved patient outcomes. Thus, this study underscored the pivotal role of HOX gene dysregulation in ESCC and classified HOXA7 as a potential prognostic biomarker in this tumor.
    Journal
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    HOXA2 (Homeobox A2) • HOXB13 (Homeobox B13) • HOXB2 (Homeobox B2) • HOXC10 (Homeobox C10) • HOXC13 (Homeobox C13)
    over1year
    Comprehensive analysis of single-cell transcriptomics and genetic factors reveals the mechanisms and preventive strategies for the progression from pulmonary fibrosis to lung cancer. (PubMed, Int Immunopharmacol)
    CFB promotes lung cancer occurrence by inducing the accumulation and polarization of a large number of monocytes/macrophages in the lungs, driving disease progression by reducing the physical fitness of patients with pulmonary fibrosis.
    Journal
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    CFB (Complement Factor B) • ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) • HOXB2 (Homeobox B2)
    over1year
    Exosomal mRNA in plasma serves as a predictive marker for microvascular invasion in hepatocellular carcinoma. (PubMed, J Gastroenterol Hepatol)
    This study unveils the potential of exosome-derived PRPSAP1 in plasma as a promising indicator for predicting MVI status preoperatively.
    Journal
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    HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2)
    over1year
    Oncogenic Role of SATB2 In Vitro: Regulator of Pluripotency, Self-Renewal, and Epithelial-Mesenchymal Transition in Prostate Cancer. (PubMed, Cells)
    The expression of SATB2 was significantly higher in prostate adenocarcinoma compared to normal tissues. Overall, our data suggest that SATB2 acts as an oncogenic factor where it is capable of inducing malignant changes in PrECs by inducing CSC characteristics.
    Preclinical • Journal • IO biomarker
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • CD44 (CD44 Molecule) • KLF4 (Kruppel-like factor 4) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • CDH2 (Cadherin 2) • XIAP (X-Linked Inhibitor Of Apoptosis) • NANOG (Nanog Homeobox) • SNAI2 (Snail Family Transcriptional Repressor 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2) • SATB2 (SATB Homeobox 2)
    over1year
    HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer. (PubMed, J Ovarian Res)
    These results verified that high expression of HOXB2 correlated with platinum resistance and poor prognosis of OV. Therefore, targeting HOXB2 may be a promising strategy for OV therapy.
    Journal
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    ABCA1 (ATP Binding Cassette Subfamily A Member 1) • ABCG1 (ATP Binding Cassette Subfamily G Member 1) • DANCR (Differentiation Antagonizing Non-Protein Coding RNA) • HOXB2 (Homeobox B2)
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    cisplatin
    almost2years
    Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1. (PubMed, Int J Med Sci)
    Our findings showed that HOXB2 acts as a tumor promoter in NPC, activating malignant behaviors and radioresistance of tumors via FOXO1 regulation. Moreover, the inactivation of HOXB2 or activation of FOXO1 are potential strategies to inhibit tumor progression and overcome radioresistance in NPC.
    Journal
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    FOXO1 (Forkhead box O1) • HOXB2 (Homeobox B2)
    2years
    The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling. (PubMed, Int J Biol Sci)
    Further, we found the long non-coding RNA HOXB-AS1 in complex with SMYD3, a lysine methyltransferase, as an epigenetic switch controlling HOXB2 expression. Overall, our results indicate a tumor-suppressive role of HOXB2 by maintaining ECM organization and delineate potential clinical utility of HOXB2 as a marker for TNBC patients.
    Journal
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    ECM2 (Extracellular Matrix Protein 2) • SMYD3 (SET And MYND Domain Containing 3) • HOXB2 (Homeobox B2) • MATN3 (Matrilin 3)