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    GENE:

    HOXA2 (Homeobox A2)

    i
    Other names: HOXA2, Homeobox A2, HOX1K, Homeobox Protein Hox-A2, Homeobox Protein Hox-1K, Homeo Box A2, MCOHI
    Associations

    News

    Trials
    1year
    Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival. (PubMed, Cell Death Differ)
    Specifically, depletion of HOXA2 leaded to a concomitantly decreased expression of PPARγ and its target CIDEC, a master regulator of lipid droplet (LD) accumulation, thereby resulting in reduced LD abundance in BC cells. In summary, our study identifies HOXA2 as a novel prognosis-relevant tumor suppressor in the mammary gland.
    Journal
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    PPARG (Peroxisome Proliferator Activated Receptor Gamma) • HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2)
    1year
    HOXA7 Expression Is an Independent Prognostic Biomarker in Esophageal Squamous Cell Carcinoma. (PubMed, Genes (Basel))
    This finding opens new possibilities for targeted therapies, offering hope for improved patient outcomes. Thus, this study underscored the pivotal role of HOX gene dysregulation in ESCC and classified HOXA7 as a potential prognostic biomarker in this tumor.
    Journal
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    HOXA2 (Homeobox A2) • HOXB13 (Homeobox B13) • HOXB2 (Homeobox B2) • HOXC10 (Homeobox C10) • HOXC13 (Homeobox C13)
    over1year
    Exosomal mRNA in plasma serves as a predictive marker for microvascular invasion in hepatocellular carcinoma. (PubMed, J Gastroenterol Hepatol)
    This study unveils the potential of exosome-derived PRPSAP1 in plasma as a promising indicator for predicting MVI status preoperatively.
    Journal
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    HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2)
    over1year
    Oncogenic Role of SATB2 In Vitro: Regulator of Pluripotency, Self-Renewal, and Epithelial-Mesenchymal Transition in Prostate Cancer. (PubMed, Cells)
    The expression of SATB2 was significantly higher in prostate adenocarcinoma compared to normal tissues. Overall, our data suggest that SATB2 acts as an oncogenic factor where it is capable of inducing malignant changes in PrECs by inducing CSC characteristics.
    Preclinical • Journal • IO biomarker
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • CD44 (CD44 Molecule) • KLF4 (Kruppel-like factor 4) • SOX2 • POU5F1 (POU Class 5 Homeobox 1) • CDH2 (Cadherin 2) • XIAP (X-Linked Inhibitor Of Apoptosis) • NANOG (Nanog Homeobox) • SNAI2 (Snail Family Transcriptional Repressor 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2) • SATB2 (SATB Homeobox 2)
    over2years
    LncRNA-LINC00472 suppresses the malignant progression of non-small cell lung cancer via modulation of the miRNA-1275/Homeobox A2 axis. (PubMed, Adv Clin Exp Med)
    The LINC00472 functioned as a competing endogenous RNA to modulate HOXA2 level by sponging miR-1275 in NSCLC. Simultaneously, the LINC00472/miR-1275/HOXA2 axis may be a possible therapeutic target and biomarker for NSCLC.
    Journal
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    HOXA2 (Homeobox A2) • HOXB2 (Homeobox B2) • MIR127 (MicroRNA 127)