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    GENE:

    HOXA13 (Homeobox A13)

    i
    Other names: HOXA13, Homeobox A13, HOX1J, Homeobox Protein Hox-A13, Homeobox Protein Hox-1J, Homeo Box A13, HOX1, Transcription Factor HOXA13, Homeobox Protein HOXA13, Homeo Box 1J
    Associations

    News

    Trials
    26d
    CircCCDC66 promotes the progression and EMT of renal cell carcinoma via the miR-1278/HOXA13 axis. (PubMed, J Transl Med)
    CircCCDC66 is upregulated in ccRCC and promotes tumorigenesis and progression by acting as a miR-1278 sponge to derepress HOXA13 expression.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • HOXA13 (Homeobox A13) • MIR127 (MicroRNA 127)
    2ms
    HOXA13 overexpression is associated with poor prognosis in colorectal liver metastases☆. (PubMed, Surg Oncol Insight)
    HOXA13, HOXD4, and HOXD8 were explored in five independent cohorts. HOX genes and their associated lncRNAs exhibit prognostic associations in patients with CRCLM and may act as biomarkers to refine clinical decision-making.
    Journal
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    HOXD8 (Homeobox D8) • HOTTIP (HOXA Distal Transcript Antisense RNA) • HOXA11-AS (HOXA11 Antisense RNA) • HOXA13 (Homeobox A13)
    4ms
    HOXA13 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating SLC7A11 and SLC3A2. (PubMed, Cell Signal)
    HOXA13 drives PCa progression by transcriptionally activating SLC7A11 and SLC3A2, which suppress ferroptosis and enhance proliferation and metastasis. The findings highlighted sh-HOXA13 promoting ferroptosis as a potential strategy for PCa treatment.
    Journal
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    SLC3A2 (Solute Carrier Family 3 Member 2) • SLC7A11 (Solute Carrier Family 7 Member 11) • HOXA13 (Homeobox A13)
    10ms
    Acute lymphoblastic leukaemia with T- and B-lineage defining markers. (PubMed, Pathology)
    The majority of cases represent early T-precursor lymphoblastic leukaemia expressing aberrant B-cell markers. We also showed persistent CD19 expression in relapsed/residual disease (16/17, 94%), suggesting its potential role as a therapeutic target and as a marker for detection of residual/relapse disease in these ALL cases.
    Journal
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    ABL1 (ABL proto-oncogene 1) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • NOTCH1 (Notch 1) • CD19 (CD19 Molecule) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CD22 (CD22 Molecule) • PAX5 (Paired Box 5) • JAK3 (Janus Kinase 3) • NUP214 (Nucleoporin 214) • CD79A (CD79a Molecule) • MME (Membrane Metalloendopeptidase) • PHF6 (PHD Finger Protein 6) • BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B) • HOXA13 (Homeobox A13) • MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor) • SPTAN1 (Spectrin Alpha Non-Erythrocytic 1)
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    CDKN2A deletion
    12ms
    HOXA13 promotes immune evasion in bladder cancer by suppressing antigen processing and presentation, and phagosome pathways. (PubMed, Funct Integr Genomics)
    While the role of HOXB13 in bladder cancer progression requires further delineation, the primary focus of this study is on HOXA13 due to its involvement in immune evasion mechanisms. This study provides novel insights into the potential therapeutic strategies for targeting HOXA13 in bladder cancer, and highlights the distinct roles of HOXA13 and HOXB13 in bladder carcinogenesis.
    Journal
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    HOXA13 (Homeobox A13) • HOXB13 (Homeobox B13)
    1year
    Circ_0070934 Regulates the Proliferation, Metastasis, and Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Targeting miR-203a-3p/HOXA13 Axis. (PubMed, J Biochem Mol Toxicol)
    These data revealed that circ_0070934 was important for maintaining the malignant phenotype of CRC cells, and circ_0070934 knockdown undermined CRC cell malignancy. Targeting circ_0070934/miR-203a-3p/HOXA13 axis is the promising intervention approach for managing CRC.
    Journal
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    HOXA13 (Homeobox A13) • MIR203A (MicroRNA 203a)
    1year
    Integrative analysis of bulk RNA and single-cell sequencing data reveals a liquid-liquid phase separation signature for clear cell renal cell carcinoma. (PubMed, Gene)
    Finally, the expression of the signature genes was verified in ccRCC cells, and the effect of SGO1 on the malignant biological behavior of ccRCC cells was also verified by in vitro experiments. In conclusion, this LLPS prognostic signature may be a potential clinical prognostic and immunotherapeutic response-related indicator for ccRCC patients.
    Journal • IO biomarker
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    KMT5C (Lysine Methyltransferase 5C) • HOXA13 (Homeobox A13) • TEAD4 (TEA Domain Transcription Factor 4)
    over1year
    Analytical Validation of Cxbladder® Detect, Triage, and Monitor: Assays for Detection and Management of Urothelial Carcinoma. (PubMed, Diagnostics (Basel))
    Cxbladder had high analytical accuracy (≤10.63% inaccuracy across all biomarkers) and good reproducibility (>85% concordance between laboratories). Cxbladder accurately and reproducibly detects UC biomarker expression and can aid clinicians in risk stratification of hematuria patients or those undergoing surveillance for recurrent UC.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • HOXA13 (Homeobox A13)
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    Cxbladder
    over1year
    Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fate. (PubMed, bioRxiv)
    We also found that our metastatic potential signature is enriched in other human carcinomas, suggesting that it is conserved across epithelial malignancies. This work establishes a strategy for linking cancer cell state to future behavior, reveals novel functional regulators of PDAC metastasis, and establishes a method for scoring human carcinomas based on metastatic potential.
    Journal • Gene Signature • Metastases
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    CDX2 (Caudal Type Homeobox 2) • IL23A (Interleukin 23 Subunit Alpha) • HOXA13 (Homeobox A13)
    over1year
    Expression profile of long noncoding RNAs and comprehensive analysis of lncRNA-cisTF-DGE regulation in condyloma acuminatum. (PubMed, BMC Med Genomics)
    CA has a specific lncRNA profile, and the differentially expressed lncRNAs play regulatory roles in mRNA expression through cis-acting TFs, which provides insight into their regulatory networks. It will be useful to understand the pathogenesis of CA to provide new directions for the prevention, clinical treatment and efficacy evaluation of CA.
    Journal
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    HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA) • HOXA13 (Homeobox A13)
    almost2years
    Application of PLK1 and HOXA13 Gene Expression Levels in Urine in the Diagnosis of Non-muscle Invasive Bladder Cancer. (PubMed, Biochem Genet)
    HOXA13 and PLK 1 exhibited adequate specificity and sensitivity for diagnosis. The results of this research showed that despite the higher expression of these genes in urine, only HOXA13 and PLK1 had sufficient and proper specificity and sensitivity, so the urinary expression of these two genes can be used in future studies for diagnosis and monitoring in cancer bladder.
    Journal
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    FGFR3 (Fibroblast growth factor receptor 3) • PLK1 (Polo Like Kinase 1) • HOXA13 (Homeobox A13)
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    FGFR3 expression
    almost2years
    Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy. (PubMed, Transl Cancer Res)
    The immune-related analyses revealed that the low-risk group would benefit more from immunotherapy. The prognostic model of ccRCC based on six renin secretion pathway-related genes can be used to guide the precise treatment of ccRCC patients.
    Journal
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    CDC20 (Cell Division Cycle 20) • IGFBP3 (Insulin-like growth factor binding protein 3) • HOXA13 (Homeobox A13)