^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    HOXA11 (Homeobox A11)

    i
    Other names: Homeobox A11, Homeobox Protein Hox-A11, Homeobox Protein Hox-1I, HOX1I, Homeobox Protein HOXA11, Homeo Box A11, Homeo Box 1I, RUSAT1, HOXA11, HOX1
    2ms
    Integrating multi-omics and clinical features to model survival in epithelial ovarian cancer subtypes. (PubMed, Sci Rep)
    Integrating multivariate predictive modeling with biological interpretation provides a comprehensive framework for personalized risk stratification and treatment decision-making in EOC. The identified prognostic biomarkers, such as TPM4, SDHD, MUC16, and BCL6, represent potential targets for future studies and therapeutic interventions.
    Journal
    |
    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog) • ARID1A (AT-rich interaction domain 1A) • BCL6 (B-cell CLL/lymphoma 6) • WT1 (WT1 Transcription Factor) • MUC16 (Mucin 16, Cell Surface Associated) • FAT3 (FAT Atypical Cadherin 3) • ZFHX3 (Zinc Finger Homeobox 3) • FAT4 (FAT Atypical Cadherin 4) • CSMD3 (CUB And Sushi Multiple Domains 3) • HOXA11 (Homeobox A11) • SDHD (Succinate Dehydrogenase Complex Subunit D) • TPM4 (Tropomyosin 4)
    |
    TP53 mutation • PIK3CA mutation • PTEN mutation • ARID1A mutation
    4ms
    HOXA10 and HOXA11 Methylation: Epigenetic Barriers to Endometrial Receptivity in ART. (PubMed, Genes (Basel))
    This review consolidates the current body of knowledge regarding the epigenetic regulation of endometrial receptivity. It outlines fundamental scientific data on epigenetic mechanisms and discusses contemporary diagnostic and pharmacological intervention strategies.
    Review • Journal
    |
    HOXA11 (Homeobox A11) • HOXA10 (Homeobox A10)
    5ms
    LncRNA HOXA11-AS promotes the cell proliferation, migration, invasion and inhibits cell apoptosis in esophageal squamous cell carcinoma. (PubMed, Sci Rep)
    LncRNA HOXA11-AS is aberrantly overexpressed in ESCC and functions as an oncogene, driving tumor progression by enhancing proliferation, migration, invasion and suppressing apoptosis. Its association with poor prognosis identifies HOXA11-AS as a promising prognostic biomarker and potential therapeutic target for ESCC.
    Journal
    |
    HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
    7ms
    Thin endometrium restricts peri-ovulatory physiological transition between anti-adhesive and adhesive receptivity modulators. (PubMed, Reprod Biomed Online)
    Endometrial thinning causes defective expression of anti-adhesive and adhesive receptivity modulators, restricting the transition of the endometrium from a non-receptive to a receptive state.
    Journal
    |
    HOXA11 (Homeobox A11) • PODXL (Podocalyxin) • HOXA10 (Homeobox A10)
    7ms
    Multifaceted regulation of the HOX cluster and its implications in oral cancer. (PubMed, Clin Epigenetics)
    The functional consequence of HOX genes dysregulation was driven by diverse DNA and RNA epigenetic mechanisms affecting the transcriptional and post-transcriptional regulation contributing to the oral cancer progression.
    Journal
    |
    HOXA11 (Homeobox A11) • HOXB9 (Homeobox B9) • HOXC10 (Homeobox C10) • HOXC13 (Homeobox C13)
    8ms
    EZH2: A Crucial Competing Endogenous RNA in Cancer Research-A Scoping Review. (PubMed, Adv Biomed Res)
    This scoping review highlights the diversity of EZH2-containing ceRNA axes in cancer, suggesting their potential as therapeutic targets. Further studies are needed to clarify their roles and clinical utility.
    Review • Journal
    |
    EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA) • XIST (X Inactive Specific Transcript) • MIR124-3 (MicroRNA 124-3)
    9ms
    RETRACTED: Zhou et al. HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association. Cancers 2022, 14, 3694. (PubMed, Cancers (Basel))
    The journal retracts the article "HOXA11-AS1 promotes PD-L1-mediated immune escape and metastasis of hypopharyngeal carcinoma by facilitating PTBP1 and FOSL1 association" [...].
    Journal
    |
    PD-L1 (Programmed death ligand 1) • FOSL1 (FOS Like 1) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
    9ms
    Transcriptional landscape of pleural mesothelioma patients in relation to NF2 gene mutational status. (PubMed, J Egypt Natl Canc Inst)
    NF2 mutations influence the tumor microenvironment, transcriptional landscape, and predicted therapeutic response in PM, underscoring their potential as prognostic biomarkers. These findings support tailored therapeutic strategies targeting NF2-related pathways, including Hippo signaling and cytokine modulation.
    Journal
    |
    NRG1 (Neuregulin 1) • NF2 (Neurofibromin 2) • FGF2 (Fibroblast Growth Factor 2) • HOXA11 (Homeobox A11)
    |
    vinblastine
    9ms
    The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. (PubMed, Reprod Biol Endocrinol)
    HOXA11-AS is a critical regulator of normal endometrial development. HOXA11-AS is elevated in endometriosis contributes to its pathophysiology. This long non-coding RNA was decreased in women undergoing endometriosis treatment with progestins. HOXA11-AS regulated several key drivers of disease and repression during treatment likely has a central role in preventing growth and invasion of endometriosis.
    Journal • IO biomarker
    |
    PTEN (Phosphatase and tensin homolog) • BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • MMP2 (Matrix metallopeptidase 2) • CASP3 (Caspase 3) • MMP9 (Matrix metallopeptidase 9) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA) • ITGB3 (Integrin Subunit Beta 3)
    9ms
    Long non-coding RNA HOXA11-AS inhibits apoptosis, induces proliferation, and promotes autophagy via the miR-214-3p/ATG12 axis in acute T lymphoblastic leukemia. (PubMed, J Mol Histol)
    In addition, HOXA11-AS modulated ATG12 via sponging miR-214-3p. Overall, this research indicated that lncRNA HOXA11-AS not only stimulates cell proliferation and autophagy but also inhibits apoptosis via the miR-214-3p/ATG12 axis, thereby suggesting that lncRNA HOXA11-AS might be a new candidate for T-ALL diagnosis and therapy.
    Journal
    |
    HOXA11 (Homeobox A11) • ATG12 (Autophagy Related 12) • HOXA11-AS (HOXA11 Antisense RNA) • MIR214 (MicroRNA 214)
    10ms
    Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11. (PubMed, Transl Oncol)
    Estrogen and its related proteins have therapeutic effects in HCC and may be new potential therapeutic targets.
    Journal
    |
    MET (MET proto-oncogene, receptor tyrosine kinase) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
    10ms
    HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction. (PubMed, Biomolecules)
    Furthermore, regulatory pathways involving vitamin D and retinoic acid offer promising therapeutic avenues pathways, as they enhance HOXA10/HOXA11 expression and endometrial receptivity. This review underscores the critical molecular roles of HOXA10/HOXA11 genes as biomarkers and therapeutic targets to optimize fertility outcomes and address reproductive pathologies.
    Review • Journal
    |
    HOXA11 (Homeobox A11) • HOXA10 (Homeobox A10) • LIF (LIF Interleukin 6 Family Cytokine)