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    BIOMARKER:

    HOXA11 overexpression

    i
    Other names: Homeobox A11, Homeobox Protein Hox-A11, Homeobox Protein Hox-1I, HOX1I, Homeobox Protein HOXA11, Homeo Box A11, Homeo Box 1I, RUSAT1, HOXA11, HOX1
    Entrez ID:
    3207
    almost2years
    Targeting HOXA11-AS to mitigate prostate cancer via the glycolytic metabolism: In vitro and in vivo. (PubMed, J Cell Mol Med)
    HOXA11-AS silencing significantly inhibited tumour development in vivo. In summary, silencing HOXA11-AS can inhibit PCa by regulating glucose metabolism and may provide a future guidance for the treatment of PCa.
    Preclinical • Journal
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    HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
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    HOXA11 overexpression
    almost2years
    Hypoxia/inflammation-induced upregulation of HIF-1α and C/EBPβ promotes nephroblastoma cell EMT by improving HOXA11-AS transcription. (PubMed, Heliyon)
    We demonstrated that hypoxia/inflammation-induced upregulation of HIF-1α and C/EBPβ promoted nephroblastoma EMT by improving HOXA11-AS transcription. HOXA11-AS might be a therapy target for nephroblastoma.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
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    HIF1A expression • HOXA11 overexpression
    over2years
    Tumor-mesothelium HOXA11-PDGF BB/TGF β1-miR-181a-5p-Egr1 feedforward amplifier circuity propels mesothelial fibrosis and peritoneal metastasis of gastric cancer. (PubMed, Oncogene)
    Correspondingly, Egr1 over-expressed HMrSV5 cells supported migration and peritoneal dissemination of GC cells. Together our results suggest that a feedforward amplifier circuity governing GC cells and mesothelial cells in peritoneum contribute to peritoneal metastasis of GC cells.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • HOXA11 (Homeobox A11) • EGR1 (Early Growth Response 1) • MIR181A1 (MicroRNA 181a-1)
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    HOXA11 overexpression
    over2years
    LncRNA HOXA11-AS modulates the miR-148b-3p/MLPH axis to promote prostate cancer cell proliferation. (PubMed, Cell Mol Biol (Noisy-le-grand))
    MLPH was positively associated with HOXA11-AS and overexpressed it accelerated the progression of prostate cancer. Taken together, HOXA11-AS elevated MLPH expression by sponging miR-148b-3p and accelerated prostate cancer cell proliferation.
    Journal
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    CASP3 (Caspase 3) • HOXA11 (Homeobox A11) • MLPH (Melanophilin) • HOXA11-AS (HOXA11 Antisense RNA) • MIR148B (MicroRNA 148b)
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    HOXA11 overexpression
    3years
    HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy. (PubMed, Mol Med)
    HOXA11-OS is involved in the occurrence and development of LN by regulating podocyte autophagy through miR-124-3p/Cyr61 sponging, which may provide a good potential therapeutic target for LN.
    Journal
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    HOXA11 (Homeobox A11) • CCN1 (Cellular Communication Network Factor 1)
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    HOXA11 overexpression
    over3years
    HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association. (PubMed, Cancers (Basel))
    HOXA11-AS1 promoted PD-L1 expression by upregulating FOSL1 levels through PTBP1, thereby facilitating immune escape, proliferation, and metastasis of HSCC cells.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)
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    PD-L1 expression • CD8 overexpression • HOXA11 overexpression • PTBP1 overexpression
    almost4years
    Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model: Hoxa11 in myeloid sarcoma formation. (PubMed, Neoplasia)
    Although silencing Hoxa11 in leukemia cells did not affect Cxcr4 expression, it resulted in increased transwell migration, motility in confined spaces 3 μm in size, and cell protrusion. Our results revealed that Hoxa10 plays an important role in survival and Hoxa11 contributes to MS formation in MLL-t acute myeloid leukemia with activating KRAS mutation.
    Preclinical • Journal
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    KRAS (KRAS proto-oncogene GTPase) • KMT2A (Lysine Methyltransferase 2A) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • HOXA11 (Homeobox A11)
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    KRAS mutation • KRAS wild-type • RAS wild-type • MLL translocation • CXCR4 expression • HOXA11 overexpression
    almost4years
    Long Non-coding RNA HOXA11-AS Facilitates Proliferation of Lung Adenocarcinoma Cells via Targeting the Let-7c-5p/IGF2BP1 Axis. (PubMed, Front Genet)
    Experiments on mice confirmed that HOXA11-AS facilitated LUAD cell growth in vivo through regulating the let-7c-5p/IGF2BP1 axis. HOXA11-AS promoted LUAD cell proliferation by targeting let-7c-5p/IGF2BP1, which could be potential molecular targets for LUAD.
    Journal
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    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • HOXA11 (Homeobox A11) • Let-7c (MicroRNA Let-7c)
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    IGF2 overexpression • IGF2BP1 overexpression • HOXA11 overexpression
    over4years
    LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer. (PubMed, Eur Rev Med Pharmacol Sci)
    This newly identified HOXA11-AS/miR-24-3p/JPT1 axis may provide novel angle for the better control of PCa.
    Journal
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    HOXA11 (Homeobox A11)
    |
    HOXA11 overexpression