HOTTIP (HOXA Distal Transcript Antisense RNA)

Our results showed that the association between HOTTIP gene polymorphisms and NHL incidence has a significant pattern. More studies in larger populations and various ethnicities are recommended to confirm our findings.

Additionally, carriers of the rs2067087 "CG+GG" polymorphic variants were associated with a lower risk of developing advanced clinical stages. In conclusion, our findings suggest that the HOTTIP rs3807598 and rs2067087 polymorphisms may serve as pivotal predictor for assessing oral cancer progression.

These findings indicate that lncRNA expression in fibroids is modulated by menopausal status, likely reflecting hormonal influence. Hormone-responsive lncRNAs may play key roles in fibroid pathogenesis and represent potential targets for therapeutic intervention.

Together, our findings demonstrate that the lncRNA HOTTIP, a novel effector of the Hh pathway, drives colorectal cancer progression by promoting HUWE1-dependent ubiquitin‒proteasome degradation of p53. These findings reveal critical roles of the Hh-HOTTIP-p53 signaling axis in colorectal cancer progression and suggest a potential therapeutic target for colorectal cancer.

These are other questions we aimed to answer, in addition to providing insight into its function in chemotherapeutic resistance and its usefulness in the diagnosis and prognosis of numerous malignancies. Finally, we also show how mutations in this lncRNA, even in a single nucleotide, affect many diseases' fates including malignancies and other non-malignant ones.

In the present study, HOTTIP was found to be downregulated in the Erastin‑treated OS cells...Mechanically, HOTTIP recruited the RNA binding protein DiGeorge Critical Region 8 (DGCR8) and influenced its protein stability, which disrupted miR‑214‑3p biogenesis and facilitated the de‑repression of glutathione peroxidase 4 transcription, eventually leading to preventing ferroptosis. Taken together, the present study demonstrated that HOTTIP suppressed ferroptosis in OS cells via DGCR8/micro RNA 214‑3p/GPX4 regulatory axis, which might provide insights to develop HOTTIP as a promising therapeutic target for OS patients.

Hottip emerges as a promising therapeutic target for enhancing bone regeneration. These findings contribute valuable insights into lncRNA-mediated mechanisms governing skeletal dynamics.

The newly developed EV-lncRNA signature effectively identified EOGC patients at a resectable stage with enhanced precision, thereby improving the prognosis of patients who would have otherwise missed the curative treatment window.

Understanding the functional roles of HOTTIP in these cancers is essential for developing targeted therapeutic strategies. This review aims to explore the emerging roles of HOTTIP in breast and gynecologic cancers.

We found that HOTTIP gene polymorphisms were associated with a reduced likelihood of neuroblastoma in Chinese children. Further studies with large cohorts and diverse ethnicities are warranted to verify our results.

Furthermore, it investigates the clinical applicability of novel biomarkers and therapeutic strategies in CRC. Abbreviations: ncRNAs, non-coding RNAs; CRC, Colorectal cancer; EV, extracellular vesicle; mRNAs, messenger RNAs; miRNAs, microRNAs; lncRNAs, long non-coding RNAs; circRNAs, circular RNAs; HOTTIP, HOXA transcript at the distal tip; NSCLC, non-small cell lung cancer; 5-FU, 5-fluorouracil; OX, Oxaliplatin; PDCD4, programmed cell death factor 4; Tregs, regulatory T cells; EMT, epithelial-mesenchymal transition; PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; USP2, ubiquitin carboxyl-terminal hydrolase 2; TNM, tumor node metastasis; TAMs, tumor-associated macrophages; RASA1, RAS p21 protein activator 1; PDCD4, programmed cell death 4; ZBTB2, zinc finger and BTB domain containing 2; SOCS1, suppressor of cytokine signaling 1; TUBB3, β-III tubulin; MSCs, mesenchymal stem cells.

We discuss how specific HOX ncRNA networks are leveraged by leukemic cells, presenting an opportunity to explore targeted therapies and address the molecular heterogeneity of AML. Additionally, the aberrant expression of HOX ncRNAs such as HOXB derived ncRNAs in NPM1 mutated AML suggests their potential utility as improved biomarkers and for prognostication of patients with specific molecular aberrations.