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    BIOMARKER:

    HOTAIR underexpression

    i
    Other names: HOTAIR, HOX Transcript Antisense RNA, HOX Transcript Antisense RNA (Non-Protein Coding), HOXC Cluster Antisense RNA 4 (Non-Protein Coding), HOTAIR 2, Hox Transcript Antisense Intergenic RNA, Non-Protein Coding RNA 72, NONHSAG011264, HSALNG0091318, HOXC11-AS1, NCRNA00072, HOXC-AS4, HOXAS
    Entrez ID:
    100124700
    Related biomarkers:
    Expression
    1year
    A Comparative Meta-Analysis on the Association of lncRNAs MALAT1, HOTAIR, and AFAP1-AS1 With the Risk of Developing Lymph Node Metastasis in Lung Cancer. (PubMed, Cancer Rep (Hoboken))
    This study suggested that LNM in lung cancer patients is associated mostly with an elevated AFAP1-AS1 lncRNA level among the pool of three lncRNAs analyzed. Before these results can be implemented in a clinical setting, it is essential to conduct further validation and undertake comprehensive analysis to ensure robustness and reliability.
    Clinical • Retrospective data • Review • Journal
    |
    MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • HOTAIR (HOX Transcript Antisense RNA) • AFAP1-AS1 (AFAP1 Antisense RNA 1)
    |
    HOTAIR underexpression
    over3years
    Long non-coding RNA HOTAIR regulates the stemness of breast cancer cells via activation of the NF-κB signaling pathway. (PubMed, J Biol Chem)
    Our data suggest that HOTAIR-mediated NF-κB signaling primes breast CSC self-renewal and tumor propagation. In sum, we have identified HOTAIR-based NF-κB signaling regulatory circuit that promotes tumorigenic activity in breast cancer stem cells, further indicating that HOTAIR could be a promising target for clinical treatment of breast cancers.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • HOTAIR (HOX Transcript Antisense RNA) • NFKBIA (NFKB Inhibitor Alpha 2)
    |
    MYC expression • CCND1 expression • HOTAIR underexpression
    almost5years
    Correlations of HOTAIR expression with pathological stage, CT characteristics and prognosis of patients with papillary thyroid carcinoma. (PubMed, J BUON)
    The expression level of HOTAIR is distinctly increased in PTC tissues and has a positive correlation with the pathological stage and poor prognosis of patients. HOTAIR can serve as a diagnostic or prognostic marker for patients with papillary thyroid carcinoma.
    Clinical • Journal
    |
    VEGFA (Vascular endothelial growth factor A) • HOTAIR (HOX Transcript Antisense RNA)
    |
    VEGFA expression • HOTAIR underexpression