^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    HOTAIR underexpression

    i
    Other names: HOTAIR, HOX Transcript Antisense RNA, HOX Transcript Antisense RNA (Non-Protein Coding), HOXC Cluster Antisense RNA 4 (Non-Protein Coding), HOTAIR 2, Hox Transcript Antisense Intergenic RNA, Non-Protein Coding RNA 72, NONHSAG011264, HSALNG0091318, HOXC11-AS1, NCRNA00072, HOXC-AS4, HOXAS
    Entrez ID:
    100124700
    Related biomarkers:
    Expression
    over1year
    Long non-coding RNA HOTAIR regulates the stemness of breast cancer cells via activation of the NF-κB signaling pathway. (PubMed, J Biol Chem)
    Our data suggest that HOTAIR-mediated NF-κB signaling primes breast CSC self-renewal and tumor propagation. In sum, we have identified HOTAIR-based NF-κB signaling regulatory circuit that promotes tumorigenic activity in breast cancer stem cells, further indicating that HOTAIR could be a promising target for clinical treatment of breast cancers.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • HOTAIR (HOX Transcript Antisense RNA) • NFKBIA (NFKB Inhibitor Alpha 2)
    |
    MYC expression • CCND1 expression • HOTAIR underexpression
    3years
    Correlations of HOTAIR expression with pathological stage, CT characteristics and prognosis of patients with papillary thyroid carcinoma. (PubMed, J BUON)
    The expression level of HOTAIR is distinctly increased in PTC tissues and has a positive correlation with the pathological stage and poor prognosis of patients. HOTAIR can serve as a diagnostic or prognostic marker for patients with papillary thyroid carcinoma.
    Clinical • Journal
    |
    VEGFA (Vascular endothelial growth factor A) • HOTAIR (HOX Transcript Antisense RNA)
    |
    VEGFA expression • HOTAIR underexpression