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    DRUG CLASS:

    HOTAIR inhibitor

    Related drugs:
    12ms
    Compound AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of tazemetostat in endometrial cancer. (PubMed, Cancer Lett)
    Our results advocate AQB, a recently discovered small-molecule inhibitor, as a promising agent against EC cells. When combined with TAZ, it offers a novel therapeutic strategy for EC treatment.
    Journal
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    HOTAIR (HOX Transcript Antisense RNA) • SOX17 (SRY-Box Transcription Factor 17) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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    Tazverik (tazemetostat) • AC1Q3QWB