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    GENE:

    HNMT (Histamine N-Methyltransferase)

    i
    Other names: HNMT, Histamine N-Methyltransferase, HMT, HNMT-S1, HNMT-S2, MRT51
    Associations

    News

    Trials
    9ms
    HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis. (PubMed, Curr Med Sci)
    In NPC, HNMT promotes tumor growth and progression by inhibiting the IFN/TXNIP/p53 axis. These findings suggest that targeting the HNMT axis or restoring its function could provide new therapeutic strategies for NPC.
    Journal
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    TXNIP (Thioredoxin Interacting Protein) • HNMT (Histamine N-Methyltransferase)
    1year
    Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients. (PubMed, Biomark Res)
    These findings offer crucial insights for clinicians evaluating candidates for anti-HER2 therapy, especially for HER2-low breast cancer patients who could gain from T-Dxd treatment. Identifying HNMT expression could help clinicians pinpoint patients who would benefit from anti-HER2 therapy.
    Journal
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    HNMT (Histamine N-Methyltransferase)
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    HER-2 overexpression • HER-2 expression
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    Enhertu (fam-trastuzumab deruxtecan-nxki)
    over1year
    Expression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer. (PubMed, Front Oncol)
    In contrast, hsa-miR-650 is involved in the regulation of HTR6 expression, whereas hsa-miR-1275 potentially interacts with three mRNAs: ADA, SLC23A2, and HRH1. Molecular analysis confirmed that the selected mRNA and miRNA transcripts could be promising molecular markers and therapeutic targets.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • SLC3A2 (Solute Carrier Family 3 Member 2) • MIR34A (MicroRNA 34a-5p) • MIR16 (MicroRNA 16) • MIR425 (MicroRNA 425) • SLC22A3 (Solute Carrier Family 22 Member 3) • HNMT (Histamine N-Methyltransferase) • MIR127 (MicroRNA 127) • HRH2 (Histamine Receptor H2)
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    HER-2 positive
    almost4years
    HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer. (PubMed, Int J Mol Sci)
    Therefore, HNMT upregulation in NSCLC cells may upregulate HER2 expression, increasing tumorigenicity and chemoresistance through CSCs maintenance and antioxidant properties. This newly discovered regulatory axis may aid in retarding NSCLC progression and chemoresistance.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • HMOX1 (Heme Oxygenase 1) • MIR223 (MicroRNA 223) • HNMT (Histamine N-Methyltransferase)
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    HER-2 overexpression • HMOX1 expression
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    cisplatin