P=N/A, N=120, Not yet recruiting, Taipei Veterans General Hospital, Taiwan

This study constructed and validated a metabolism-driven prognostic model. The model enables prognostic stratification of LGG patients and links high-risk scores to metabolic dysregulation and an immunosuppressive microenvironment characterized by M2 macrophage enrichment, based on multi-omics data. Mechanistic exploration indicates this association is particularly pronounced in myeloid cells, predominantly within metabolism-related M2 macrophage subpopulations. Furthermore, computational analysis suggests differences in drug sensitivity between risk groups and identifies potential therapeutic compounds, providing clues for future exploration of therapeutic strategies targeting metabolic-immune interactions.

Additionally, it demonstrated good biocompatibility and exhibited no significant toxicity to major organs. Ato@DSPE-PEG-CHP specifically targeted ischemic myocardium, alleviated damage through its anti-inflammatory and antioxidant effects, and demonstrated superior efficacy and safety, presenting a promising treatment strategy for MI.

The negative control was a high cholesterol diet, and the positive control was simvastatin...A decrease in AST and ALT levels was shown by administering BBLE+SAE, and a higher mean hepatocyte cell count was observed compared to the other groups. Administration of BBLE+SAE acts as an anti-atherosclerotic and hepatoprotective agent for the liver through reducing pro-inflammatory cytokines, and its use was promising for clinical studies.

P=N/A, N=24, Not yet recruiting, Dermatology Hospital of Southern Medical University; Dermatology Hospital of Southern Medical University

P=N/A, N=22, Not yet recruiting, Shanghai Pulmonary Hospital; Shanghai Pulmonary Hospital

P=N/A, N=210, Not yet recruiting, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine; Affiliated Mental Health Center &amp

P=N/A, N=90, Recruiting, Shanghai University of Traditional Chinese Medicine; Shanghai University of Traditional Chinese Medicine

P=N/A, N=20, Completed, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital.; Jiangsu Provincial People's Hospital

P4, N=50, Not yet recruiting, Dongzhimen Hospital, Beijing University of Chinese Medicine; Dongzhimen Hospital, Beijing University of Chinese Medicine

P4, N=250, Recruiting, Shenzhen Second People's Hospital; Shenzhen Second People's Hospital

P2, N=48, Recruiting, Shanghai Ninth People's Hospital， Shanghai JiaoTong University School of Medicine; Shanghai Ninth People's Hospital， Shanghai JiaoTong University