HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1)

(-)-Gallocatechin gallate and indomethacin bound well to GZMB, while benzo(a)pyrene and benzo(e)pyrene had good binding potential with LSP1. We established lactylation as a critical regulator of AML, and GZMB and LSP1 were identified as lactylation-related clinical modeling indicators, which provides a foundation for choosing prognostic and therapeutic strategies for AML.

Particularly among those with STAT3 mutations, the 'QGXG' motif in 15 AA sequences of TCRβ complementarity-determining regions 3 (CDR3) regions was specifically recognized. These findings suggest that a specific immunogenetic background defined by particular HLA alleles, the expansion of somewhat limited T-cell clones and STAT3-mutated T cells are involved in the pathogenesis of chronic acquired PRCA.

P=N/A, N=38, Suspended, University of Wisconsin, Madison | Recruiting --> Suspended

In this review, we will describe the current status of CAR T/NK cell development for AML. We will also introduce a new CAR T-cell or NK-cell therapy that targets mismatched HLA-DRB1 in patients with AML who have relapsed following an allogeneic haematopoietic stem cell transplant.

P2, N=41, Recruiting, Milton S. Hershey Medical Center | Not yet recruiting --> Recruiting

Here, we perform single-cell RNA sequencing (RNA-seq) on 16 HNSCC patients pre- and post-neoadjuvant pembrolizumab treatment...Finally, we confirm that pre-treatment malignant-IFN/MHC-II is a marker of response through deconvolution of bulk RNA-seq data from an independent cohort. Beyond identifying the malignant IFN/MHC-II program as a potential biomarker for immunotherapy response in HNSCC, our work elucidates the important role of malignant cells in immunotherapy.

In exploratory prospective studies, our system predicted ribociclib-induced grade 3 DILI in one ER+/HER2- breast cancer patient and absence of DILI in two patients, consistent with clinical outcomes. These findings highlight the value of integrating our model with our AI-based mapping strategy to enable mechanistic classification of DILI, deconvolution of immune-related toxicity, and prediction of patient-specific risk. Our platform represents a step toward personalized hepatotoxicity assessment and improved translational toxicology strategies.

P2, N=61, Completed, Fred Hutchinson Cancer Center | Active, not recruiting --> Completed

P1/2, N=49, Recruiting, Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla | Not yet recruiting --> Recruiting

The CEC model reproduces major features of evaporative DED, including epithelial damage, GC remodeling, immune activation, and inflammation. As a non-invasive desiccating stress model, it represents a relevant experimental platform for studying ocular surface inflammation and for preclinical evaluation of therapeutic strategies.

Functional coculture assays showed that IEC organoids with cognate myelin oligodendrocyte glycoprotein antigen induce RORγt+CD4+ T cell differentiation in an MHC II-dependent manner. These findings uncover a conserved gut-central nervous system axis in autoimmunity and position epithelial antigen presentation as a key initiator of neuroinflammation.

P2, N=40, Active, not recruiting, Boston Children's Hospital | Trial primary completion date: Jul 2026 --> Dec 2026