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    BIOMARKER:

    HLA-DRA rs7192

    i
    Other names: HLA-DRA, Major Histocompatibility Complex, Class II, DR Alpha, HLA-DRA1, HLA Class II Histocompatibility Antigen, DR Alpha Chain, MHC Class II Antigen DRA, Histocompatibility Antigen HLA-DR Alpha
    Entrez ID:
    3122
    Related biomarkers:
    Expression
    Others
    over1year
    Single nucleotide polymorphisms (SNPs) in MHC class I and II genes to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3, MAVERICC, and TRIBE trials. (ASCO 2023)
    Genomic DNA from blood samples of 775 pts enrolled in three independent, randomized, first-line trials: TRIBE (FOLFIRI-bevacizumab [bev], N = 215), FIRE-3 (FOLFIRI-bev, N = 107; FOLFIRI-cetuximab [cet], N = 129) and MAVERICC (FOLFIRI-bev, N = 163; FOLFOX-bev, N = 161) was genotyped through OncoArray, a custom array manufactured by Illumina including approximately 530K SNP markers... Our results highlight an important role for MHC SNPs as prognostic and predictive biomarkers for first-line treatment in mCRC, with differential effects based on biologic agent and chemotherapy backbone. These biomarkers, when further validated, may contribute to personalized treatment strategies for mCRC patients.
    Clinical • Metastases
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    B2M (Beta-2-microglobulin) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1) • HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) • HLA-E (Major Histocompatibility Complex, Class I, E) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • TAP1 (Transporter 1) • HLA-C (Major Histocompatibility Complex, Class I, C)
    |
    CIITA rs4774 • ERAP1 rs26653 • HLA-B rs2770 • HLA-DMB rs10751 • HLA-DOB rs11244 • HLA-DPB1 rs3097671 • HLA-DRA rs7192 • HLA-G rs1610696 • TAP1 rs1135216 • TAP2 rs1044043 • TAP2 rs1800454 • TAPBP rs3106191 • TAP2 rs241447
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    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan • leucovorin calcium