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    BIOMARKER:

    HLA-DRA expression

    i
    Other names: HLA-DRA, Major Histocompatibility Complex, Class II, DR Alpha, HLA-DRA1, HLA Class II Histocompatibility Antigen, DR Alpha Chain, MHC Class II Antigen DRA, Histocompatibility Antigen HLA-DR Alpha
    Entrez ID:
    3122
    Related biomarkers:
    Mutation
    Others
    15d
    Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway. (PubMed, Int Immunopharmacol)
    This study shows that HLA-DRA and the M1/M2 ratio are indicators of favorable prognosis in patients with ccRCC. HLA-DRA promotes M1-like polarization by regulating NF-κB, which can be used as a therapeutic target to enhance anti-tumor immunity.
    Journal
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    CXCL10 (Chemokine (C-X-C motif) ligand 10) • CCL2 (Chemokine (C-C motif) ligand 2) • HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha)
    |
    HLA-DRA expression
    8ms
    A protective effect of lower MHC-II expression in MOGAD. (PubMed, J Neuroimmunol)
    Expressions of HLA-DRA was significantly lower in MOGAD patients. This reduction in HLA-DRA, correlated with a monophasic disease course and greater brain volume, enhancing our ability to predict MOGAD progression.
    Journal
    |
    HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha)
    |
    MHC-II expression • HLA-DRA expression
    9ms
    Evaluation of HLA-DR and HLA-DQ expression in gastric cancer tissues. (PubMed, J Cancer Res Ther)
    The results reported here along with future studies can be useful to understand the interplay between immune system and GC, therefore, may be helpful to design an effective immune-based therapy.
    Journal
    |
    HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1) • HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha)
    |
    HLA-DRA expression