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BIOMARKER:
HLA-DQB1*05:01
i
Other names: HLA-DQB1, Major Histocompatibility Complex Class II DQ Beta 1, CELIAC1, HLA-DQB, IDDM1, HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain, MHC Class II Antigen DQB1, MHC Class II HLA-DQ Beta Glycoprotein, MHC Class II Antigen HLA-DQ-Beta-1, MHC Class II DQ Beta Chain
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Analysis of viral sequences, HLA-DQB1 variations, cytokine polymorphisms, and genetic relationships within the phylogenetic tree revealed that 40% of CHB patients from three-generation families were infected by a shared source of transmission, as indicated by the presence of the same HBV genotype. This study underscores the complex interplay of host and viral factors that influence hepatitis B infection outcomes and suggests potential familial transmission pathways.
Eighty-two transplant-ineligible patients with newly diagnosed MM enrolled in a phase II study (JCOG1105) comparing two less intensive melphalan, prednisolone, plus Btz (MPB) regimens were subjected to HLA typing. CR was achieved in patients carrying HLA-DQB1*03:02, -DQB1*05:01, and -DRB1*01:01-class II alleles. HLA genotyping may help predict Btz-induced toxicity and treatment efficacy in patients with MM, although this needs further validation.
3 years ago
Clinical • Journal
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HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1)