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    BIOMARKER:

    HLA-A underexpression + PD-L1 expression

    i
    Other names: HLA-A, Major Histocompatibility Complex, Class I, A, HLA Class I Histocompatibility Antigen, A Alpha Chain, HLAA, HLA Class I Histocompatibility Antigen, A-1 Alpha Chain, MHC Class I Antigen HLA-A Heavy Chain, Leukocyte Antigen Class I-A, Human Leukocyte Antigen A, PD-L1, CD274, HPD-L1, PD-L1, B7H1, PDL1, Programmed death ligand 1, B7-H1, B7-H, PDCD1L1, PDCD1LG1, PDCD1 Ligand 1, B7 homolog 1, CD274 Antigen, Programmed cell death 1 ligand 1, CD274 molecule
    Entrez ID:
    29126; 3105
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    1year
    Case #4 (ATS 2023)
    Down-regulation of HLA-1 expression is a mechanism of immune-evasion and affects a subset of NSCLC, which abrogates the response to ICI. HLA-1 IHC is an emerging immunomarker in NSCLC and predictor of response to ICI. In addition, we observed that HLA-1 is co-expressed with PD-L1 and represents a surrogate marker of immune-inflamed phenotype which might predict better outcomes to PD(L)-1 blockade.
    Clinical • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8)
    |
    PD-L1 expression • CD73 expression • HLA-A underexpression + PD-L1 expression
    |
    VENTANA PD-L1 (SP263) Assay
    1year
    Profile of immunorecognition related markers including HLA-1 expression to predict response to immunocheckpoint inhibitors in non-small cell lung cancer (ELCC 2023)
    HLA-1 IHC is an emerging immunomarker in NSCLC and predictor of response to ICI. In addition, we observed that HLA-1 is co-expressed with PD-L1 and represents a surrogate marker of immune-inflamed phenotype which might predict better outcomes to PD(L)-1 blockade.
    Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8)
    |
    PD-L1 expression • CD73 expression • HLA-A underexpression + PD-L1 expression
    |
    VENTANA PD-L1 (SP263) Assay