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    GENE:

    HIVEP1 (HIVEP Zinc Finger 1)

    i
    Other names: HIVEP1, HIVEP Zinc Finger 1, PRDII-BF1, CIRIP, MBP-1, Zinc Finger Protein 40, Schnurri-1, CRYBP1, ZNF40A, ZNF40, ZAS1, Human Immunodeficiency Virus Type I Enhancer-Binding Protein 1, Human Immunodeficiency Virus Type I Enhancer Binding Protein 1, Gate Keeper Of Apoptosis-Activating Protein, Cirhin Interaction Protein, GAAP, Major Histocompatibility Complex Binding Protein 1, Major Histocompatibility Complex-Binding Protein 1, Positive Regulatory Domain II Binding Factor 1, Positive Regulatory Domain II-Binding Factor 1, HIV-EP1
    4ms
    HIVEP1 aggravates NASH by reprogramming polyamine metabolism in TH17 cells. (PubMed, Sci Transl Med)
    Consequently, pharmacological inhibition of ODC1 decreased cytokine production, alleviated inflammation, and prevented the NAFLD-to-NASH transition. Together, our findings elucidate the role of polyamine metabolism in TH17 cell-mediated NASH development and identify potential therapeutic targets for the effective treatment of NASH.
    Journal
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    CD4 (CD4 Molecule) • IL17A (Interleukin 17A) • HIVEP1 (HIVEP Zinc Finger 1)
    2years
    A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study. (PubMed, Bioinform Biol Insights)
    Three potential therapeutic compounds namely INCB3284, CCX915, and MLN-1202 were found to interact with up-regulated protein C-C chemokine receptor type 2 (CCR2) in protein-drug interaction analysis. The proposed biomarkers and therapeutic potential molecules could be investigated for potential pharmacological targets and activity in the fight against in patients with gonorrhea, chlamydia, and prostate cancer.
    Journal
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    SLFN11 (Schlafen Family Member 11) • GATA6 (GATA Binding Protein 6) • APP (Amyloid Beta Precursor Protein) • KMT2B (Lysine Methyltransferase 2B) • MIR7 (MicroRNA 7) • CCR2 (C-C Motif Chemokine Receptor 2) • HIVEP1 (HIVEP Zinc Finger 1) • SH3BGRL (SH3 Domain Binding Glutamate Rich Protein Like) • DERL1 (Derlin 1) • MARCKS (Myristoylated Alanine Rich Protein Kinase C Substrate) • PRNP (Prion Protein) • PTGS1 (Prostaglandin-Endoperoxide Synthase 1) • SLC40A1 (Solute Carrier Family 40 Member 1)
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    plozalizumab (TAK-202)