HIPK3 (Homeodomain Interacting Protein Kinase 3)

The results can contribute to a better pathophysiology understanding of AML, lead to the discovery of new diagnostic biomarkers, and develop treatment goals for patients. Also, the relationship between the genes and the clinicopathological characteristics of the patients helps patient monitoring.

High ciRS-7 and circHIPK3 were significantly associated with poor prognosis and advanced clinical features in most cancers, suggesting their potential as prognostic biomarkers.

Aberrant expression of circHIPK3 is closely associated with the disease mechanisms, diagnosis, treatment, and prognosis of NSCLC. This review discusses the latest research advancements on circHIPK3 in NSCLC, aiming to promote precise diagnosis and treatment of lung cancer..

It is often associated with cellular regulatory pathways, suggesting an important role in the molecular dynamics of tumors. The identification of biomarkers is an important tool for therapeutic improvement; thus we review the role of circHIPK3 and its potential as a biomarker in CML.

A combined treatment strategy involving oxaliplatin, rapamycin, and IWR1-1-endo effectively overcame platinum resistance induced by reduced HIPK3 expression. Monitoring HIPK3 levels could serve as a GC malignancy and platinum resistance indicator, with our proposed treatment strategy offering novel avenues for reversing resistance in gastric cancer.

These findings indicate that overexpression of miR-205-5p promotes CCA cells proliferation and migration partly via HIPK3-dependent way. Therefore, targeting miR-205-5p may be a potential treatment approach for CCA.

The positive regulation of circHIPK3/FUS/SIRT1/PGC-1α/MFN2 signaling pathway contributed to the alleviate VSMCs calcification, revealing a novel regulatory axis for vascular calcification.

In this review, we present a comprehensive summary of the oncogenic effect of circ_0000285 in various cancers, drawing on experiment performed on cell lines, animals, and human tissues. Furthermore, we predicted potential miRNAs and RNA-binding proteins that may interact with circ_0000285, thereby providing new insights for further studies.