Combination therapy with poly-ICLC, especially through IT route, and anti-PD-1 provides significantly greater antitumor effects than anti-PD-1 monotherapy in syngeneic mouse models of HCC.
6 days ago
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)
P1, N=40, Recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Dec 2025 --> Aug 2026 | Trial primary completion date: Dec 2024 --> Aug 2025
1 month ago
Trial completion date • Trial primary completion date • IO biomarker
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule)
We observed that Treg cells were able to down modulate autologous monocytes activation as well as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) production during stimulation with polyinosinic-polycytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose (poly-ICLC)...Compared to immunosuppressed participants (CD4 < 500 cells/µL), immunocompetent participants (CD4 ≥ 500 cells/µL) showed significantly higher levels of transforming growth factor beta (TGF-β) and IL-10 (p < 0.001 and p < 0.05, respectively), key cytokines used by Treg cells to exert their immunosuppressive functions. Our findings suggest the contribution of both TGF-β and IL-10 in the suppressive activity of Treg cells.
P1/2, N=0, Withdrawn, VA Office of Research and Development | N=16 --> 0 | Trial completion date: Apr 2028 --> Jun 2024 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jun 2026 --> Jun 2024
2 months ago
Enrollment change • Trial completion date • Trial withdrawal • Trial primary completion date • Checkpoint inhibition • Metastases
P1, N=40, Recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Aug 2026 --> Dec 2025 | Trial primary completion date: Aug 2025 --> Dec 2024
3 months ago
Trial completion date • Trial primary completion date • IO biomarker
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule)
P1, N=40, Recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Aug 2025 --> Aug 2026 | Trial primary completion date: Aug 2024 --> Aug 2025
3 months ago
Trial completion date • Trial primary completion date • IO biomarker
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PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule)
P1, N=20, Recruiting, Fred Hutchinson Cancer Center | Trial completion date: Nov 2025 --> Nov 2026 | Trial primary completion date: Nov 2024 --> Nov 2025
4 months ago
Trial completion date • Trial primary completion date • Metastases
Patients that exhibit higher interferon response gene expression demonstrate prolonged survival and delayed disease progression. These findings suggest that combining ATL-DC with poly-ICLC can induce a polarized interferon response in circulating monocytes and CD8+ T cells, which may represent an important blood biomarker for immunotherapy in this patient population.Trial Registration: ClinicalTrials.gov Identifier: NCT01204684.
7 months ago
Clinical • P2 data • Clinical Trial,Phase II • Journal • PD(L)-1 Biomarker • IO biomarker
P2, N=60, Active, not recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Jan 2025 --> Jan 2026 | Trial primary completion date: Jan 2024 --> Jan 2025
7 months ago
Trial completion date • Trial primary completion date
P1/2, N=75, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2024 --> Mar 2025 | Trial primary completion date: Mar 2024 --> Mar 2025
8 months ago
Trial completion date • Trial primary completion date • IO biomarker
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PD-L1 (Programmed death ligand 1) • CTAG1B (Cancer/testis antigen 1B)
P2, N=20, Recruiting, University of Alabama at Birmingham | Trial completion date: Feb 2026 --> Feb 2027 | Trial primary completion date: Feb 2025 --> Feb 2026
8 months ago
Trial completion date • Trial primary completion date
P1, N=30, Recruiting, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Trial completion date: Dec 2024 --> Aug 2025 | Trial primary completion date: Dec 2024 --> Aug 2025
9 months ago
Trial completion date • Trial primary completion date • Mismatch repair
P1/2, N=16, Not yet recruiting, VA Office of Research and Development | Trial completion date: Dec 2028 --> Apr 2028 | Trial primary completion date: Dec 2025 --> Mar 2026
9 months ago
Trial completion date • Trial primary completion date • Checkpoint inhibition • Metastases