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    BIOMARKER:

    High HDAC6 score

    i
    Other names: HDAC6, Histone Deacetylase 6, HD6, Protein Phosphatase 1, Regulatory Subunit 90, Tubulin-Lysine Deacetylase HDAC6, PPP1R90, JM21, FLJ16239, CPBHM
    Entrez ID:
    10013
    Related biomarkers:
    Expression
    Others
    over3years
    [VIRTUAL] Network-based assessment of HDAC6 activity is highly predictive of pre-clinical and clinical responses to the HDAC6 inhibitor ricolinostat (AACR 2021)
    Based on these results, we designed a phase Ib clinical trial to evaluate the activity of ricolinostat plus nab-paclitaxel in metastatic BC patients. Expansion of our analysis to other tumor types identified multiple cohorts enriched in high HDAC6 score samples. These results suggest that the HDAC6 score may provide an effective, CLIA certified predictive biomarker of ricolinostat sensitivity in multiple human cancers.
    Preclinical
    |
    HER-2 (Human epidermal growth factor receptor 2) • HDAC6 (Histone Deacetylase 6)
    |
    HER-2 negative • High HDAC6 score
    |
    albumin-bound paclitaxel • rocilinostat (ACY-1215)