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    BIOMARKER:

    HGF elevation

    i
    Other names: HGF, DFNB39, F-TCF, HGFB, HPTA, SF, Hepatocyte growth factor (hepapoietin A; scatter factor)
    Entrez ID:
    3082
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    3years
    Sphingosine 1-phosphate (S1P) produced by sphingosine kinase 1 (SphK1) and exported via ABCC1 is related to hepatocellular carcinoma (HCC) progression. (PubMed, Am J Cancer Res)
    In conclusion, simultaneous high expression of SphK1 and ABCC1 that reflect S1P export is associated with enhancement of both HCC progression and immune response. Given that S1P export was also associated with worse survival, we cannot help but speculate that pro-cancer pathways activated by S1P may overwhelm the anti-cancer immune response mediated by S1P.
    Journal
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    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • ABCC1 (ATP Binding Cassette Subfamily C Member 1) • CD4 (CD4 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • MKI67 (Marker of proliferation Ki-67) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    |
    HGF elevation
    over4years
    Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. (PubMed, Cancers (Basel))
    Blocking MET phosphorylation with adjuvant cabozantinib caused a significant improvement in photodynamic therapy efficacy, most notably by elevating spheroid necrosis at low radiant exposures. These findings highlight that adjuvant photodynamic therapy can augment chemotherapy efficacies, and potentially achieve improved management of desmoplastic PDAC in a more tolerable manner.
    Journal
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    HGF (Hepatocyte growth factor)
    |
    HGF elevation
    |
    Cabometyx (cabozantinib tablet)