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    BIOMARKER:

    HEXIM1 expression

    i
    Other names: HEXIM1, HEXIM P-TEFb Complex Subunit 1, EDG1, HIS1, MAQ1, Hexamethylene Bis-Acetamide-Inducible Protein 1, Hexamethylene Bisacetamide Inducible 1, Estrogen Down-Regulated Gene 1 Protein, Cardiac Lineage Protein 1, Menage A Quatre Protein 1, Protein HEXIM1, CLP1, Hexamethylene-Bis-Acetamide-Inducible Transcript 1, Hexamethylene Bisacetamide-Inducible Protein, Hexamethylene Bis-Acetamide Inducible 1, Hexamthylene Bis-Acetamide Inducible 1, Menage A Quatre 1, HMBA-Inducible, CLP-1
    Entrez ID:
    10614
    2years
    An alpha-herpesvirus employs host HEXIM1 to promote viral transcription. (PubMed, J Virol)
    It raises intriguing questions about whether other herpesviruses employ similar mechanisms to manipulate HEXIM1 and if this molecular target can be exploited to limit productive replication. Thus, this discovery not only contributes to our understanding of herpesvirus infection regulation but also holds implications for broader research on other herpesviruses, even DNA viruses.
    Journal
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    CDK1 (Cyclin-dependent kinase 1) • HEXIM1 (HEXIM P-TEFb Complex Subunit 1) • SOX8 (SRY-Box Transcription Factor 8)
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    MYC overexpression • HEXIM1 expression