^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    HERC3 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3)

    i
    Other names: HERC3, HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3, KIAA0032, HECT Domain And RCC1-Like Domain-Containing Protein 3, Probable E3 Ubiquitin-Protein Ligase HERC3, HECT-Type E3 Ubiquitin Transferase HERC3, Hect Domain And RLD 3
    Associations

    News

    Trials
    3years
    HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity. (PubMed, EMBO J)
    Accordingly, knockdown of HERC3 expression ameliorates tumorigenesis of breast cancer cells. Our results establish HERC3 as a critical regulator of the YAP/TAZ stability and a potential therapeutic target for breast cancer.
    Journal
    |
    ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • YAP1 (Yes associated protein 1) • HERC3 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 3) • TAFAZZIN (Tafazzin)
    |
    ERBB3 expression