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    BIOMARKER:

    HER-2 amplification + KRAS G12C

    i
    Other names: ERBB2, CD340, HER-2, HER2, NEU, NGL, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, KRAS, KRAS proto-oncogene GTPase, KRAS1, KRAS2, NS, NS3, OES, CFC2, RALD, K-Ras, RASK2, KI-RAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras 2, C-K-RAS, c-Ki-ras, c-Ki-ras2, Kirsten rat sarcoma viral oncogene homolog
    Entrez ID:
    2064; 3845
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    Associations

    News

    Trials
    over1year
    Correlation among actionable gene mutations, microsatellite instability and tumor mutational burden in advanced colorectal cancer and association with survival (AACR 2023)
    There is significant correlation among targetable genetic mutations, MSI and TMB in colorectal cancer, and biomarker profiles are associated with differences in OS. Future studies should evaluate whether combinations of targeted therapies and immunotherapy have better efficacy than monotherapy approaches in selected patients.Correlation among actionable gene mutations and immunomic signatures (OR and 95 % CI)KRAS G12CHER2 ampNTRK fusionRET fusionMSITMB >20BRAF V600E0 (0 - 0.44) *0 (0 - 0.49) *0 (0 - 6.79)0 (0 - 9.31)10.0 (7.39 - 13.5) *8.76 (6.52 - 11.7) *KRAS G12C0.31 (0.01 - 1.78)0 (0 - 16.0)0 (0 - 21.9)0.18 (0.02 - 0.67) *0.16 (0.02 - 0.61) *HER2 amp0 (0 - 17.5)0 (0 - 23.9)0.10 (0.00 - 0.57) *0.09 (0.00 - 0.51) *NTRK fusion0 (0 - 315)20.0 (4.25 - 124) *18.4 (3.91 - 115) *RET fusion24.9 (4.06 - 261) *23.0 (3.74 - 241) *MSI1.52 x 104 (4.20 x 103 - 4.50 x 1015) *
    Tumor mutational burden • Microsatellite instability • IO biomarker • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • RET (Ret Proto-Oncogene) • NTRK (Neurotrophic receptor tyrosine kinase)
    |
    BRAF V600E • KRAS G12C • HER-2 amplification • BRAF V600 • RET fusion • KRAS G12 • HER-2 amplification + KRAS G12C • NTRK fusion