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    GENE:

    HDC (Histidine Decarboxylase)

    i
    Other names: HDC, Histidine Decarboxylase
    3ms
    Overexpression of histidine decarboxylase promotes cancer cell apoptosis and migration in HN5 cells. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    However, it simultaneously promoted cell migration and upregulated the expression of MMP2, MMP7, and MMP9. These results suggest that while HDC overexpression may contribute to improved prognosis in OSCC by promoting apoptosis, its concurrent role in enhancing tumor cell migration presents a paradox that requires further investigation.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • HDC (Histidine Decarboxylase) • MMP7 (Matrix metallopeptidase 7)
    9ms
    High histamine expression by early-stage squamous cell carcinoma of the tongue is associated with a poor prognosis. (PubMed, Histol Histopathol)
    The expression of histamine may be a prognostic indicator for tongue SCC.
    Journal
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    HDC (Histidine Decarboxylase)
    1year
    HDC downregulation induced by chronic stress promotes ovarian cancer progression via the IL-6/STAT3/S100A9 pathway. (PubMed, Front Pharmacol)
    Chronic stress leads to the downregulation of HDC expression, thereby facilitating the progression of ovarian cancer through the IL-6/STAT3/S100A9 pathway. HIS might serve as a potential molecule for treating the comorbidities of ovarian cancer and depression.
    Journal
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    CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • S100A9 (S100 Calcium Binding Protein A9) • IL17A (Interleukin 17A) • HDC (Histidine Decarboxylase)
    over1year
    Histamine promotes mouse decidualization through stimulating epithelial amphiregulin release. (PubMed, FEBS J)
    Histamine increased the levels of amphiregulin (AREG) and disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) proteins, which was abrogated by treatment with famotidine, a specific histamine type 2 receptor (H2R) inhibitor, or by TPAI-1 (a specific inhibitor of ADAM17)...Additionally, AREG treatment significantly promoted in vitro decidualization. Collectively, our data suggests that blastocyst-derived TNFα induces luminal epithelial histamine secretion, and histamine increases mouse decidualization through ADAM17-mediated AREG release.
    Preclinical • Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • ADAM17 (ADAM Metallopeptidase Domain 17) • HDC (Histidine Decarboxylase)