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BIOMARKER:

HDAC5 deletion

i
Other names: HDAC5, Histone Deacetylase 5, Antigen NY-CO-9, NY-CO-9
Entrez ID:
almost2years
HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. (PubMed, Theranostics)
Our findings revealed a previously unknown role of HDAC5 in regulating the NF-κB signaling pathway and antitumor immune responses. These findings provide a strong rationale for augment the antitumor effects of ICB in immunotherapy-resistant PDAC by inhibiting HDAC5.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • HDAC5 (Histone Deacetylase 5) • RELA (RELA Proto-Oncogene)
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PD-L1 expression • HDAC5 deletion