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    GENE:

    HBA1 (Hemoglobin Subunit Alpha 1)

    i
    Other names: HBA1, Hemoglobin Subunit Alpha 1, HBA-T3, Hemoglobin Subunit Alpha, Hemoglobin, Alpha 1, Hemoglobin Alpha 1 Globin Chain, Hemoglobin Alpha Chain, Alpha-2 Globin Chain, Alpha Globin Chain, Alpha One Globin, Delta Globin, Alpha-Globin, METHBA, ECYT7, HBH
    Associations

    News

    Trials
    11ms
    Aberrant Hematopoiesis and CD8+ T-Cell Activation in Thymoma-Associated Pure Red Cell Aplasia. (PubMed, Thorac Cancer)
    Thymoma-PRCA is associated with excessive CD8 + T-cell activation and an inflammatory bone marrow environment, leading to impaired erythropoiesis. These findings provide novel insights into the immune dysregulation underlying thymoma-associated PRCA and may help identify potential therapeutic targets.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD38 (CD38 Molecule) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TNFRSF9 (TNF Receptor Superfamily Member 9) • GZMB (Granzyme B) • IRF4 (Interferon regulatory factor 4) • HBA1 (Hemoglobin Subunit Alpha 1) • HBB (Hemoglobin Subunit Beta) • MTHFD2 (Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2)
    over1year
    Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid leukemia. (PubMed, Haematologica)
    We conclude that short-term HU treatment entails differentiation of erythroid progenitor cells and alters the characteristics of LSC in CML. The results imply that studies of LSC and progenitor populations in CML should take effects of initial HU therapy into account.
    Journal
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    CD34 (CD34 molecule) • CD14 (CD14 Molecule) • HBA1 (Hemoglobin Subunit Alpha 1) • HBB (Hemoglobin Subunit Beta)
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    hydroxyurea
    over1year
    Integrative genomic analysis reveals cancer-associated mutations in patients with ophthalmic tumors. (PubMed, J Int Med Res)
    TP53 is clearly involved in ophthalmic tumorigenesis, especially in basal cell carcinoma, and the PI3K-Akt signaling pathway may be an essential pathway involved in ophthalmic tumorigenesis. RUNX1, SMO, TOP2A, and ZWINT are also highly likely to be involved in ophthalmic tumorigenesis, but further functional experiments are needed to verify the mechanisms of these genes in regulating tumorigenesis.
    Retrospective data • Journal • BRCA Biomarker
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    TP53 (Tumor protein P53) • BRCA2 (Breast cancer 2, early onset) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • RUNX1 (RUNX Family Transcription Factor 1) • BAP1 (BRCA1 Associated Protein 1) • TOP2A (DNA topoisomerase 2-alpha) • PTCH1 (Patched 1) • MUC16 (Mucin 16, Cell Surface Associated) • TTN (Titin) • HBA1 (Hemoglobin Subunit Alpha 1) • HBB (Hemoglobin Subunit Beta) • ZWINT (ZW10 Interacting Kinetochore Protein)
    almost3years
    ACQUIRED Α-THALASSEMIA IN A PATIENT WITH HIGH-RISK MYELODYSPLASTIC SYNDROME AND BONE MARROW FIBROSIS: CASE REPORT AND LITERATURE REVIEW (EHA 2023)
    Upon 2 cycles of azacytidine, the patient gradually developed hypochromic microcytic anemia... The diagnosis of ATMDS should be suspected in every older patient with MDS combined with newly onset of hypochromic microcytic anemia and absence of iron deficiency. Myelodysplastic syndrome, MDS
    Clinical • Review
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    JAK2 (Janus kinase 2) • ATRX (ATRX Chromatin Remodeler) • HBA1 (Hemoglobin Subunit Alpha 1)
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    ATRX mutation • JAK2 mutation
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    azacitidine