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    BIOMARKER:

    HAT1 overexpression

    i
    Other names: HAT1, Histone Acetyltransferase 1, KAT1, Histone Acetyltransferase Type B Catalytic Subunit
    Entrez ID:
    8520
    almost3years
    Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide. (PubMed, Clin Transl Med)
    In addition, ascorbate was observed to decrease AR expression through downregulation of HAT1 expression. Collectively, our findings reveal a novel AR signaling regulation pathway in PCa and CRPC and suggest that HAT1 serves as a critical oncoprotein and an ideal target for the treatment of ENZ resistance in CRPC patients.
    Journal • Epigenetic controller
    |
    AR (Androgen receptor) • BRD4 (Bromodomain Containing 4) • HAT1 (Histone Acetyltransferase 1)
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    AR expression • AR splice variant 7 • HAT1 overexpression
    |
    Xtandi (enzalutamide capsule)