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    GENE:

    HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1)

    i
    Other names: HAPLN1, Hyaluronan And Proteoglycan Link Protein 1, CRTL1, Cartilage-Linking Protein 1, Proteoglycan Link Protein, Cartilage Link Protein, Cartilage-Link Protein, Cartilage Linking Protein 1, CRT1
    Associations

    News

    Trials
    6ms
    Cancer-associated fibroblast marker signatures and stromal composition in usual interstitial pneumonia-associated lung adenocarcinoma: an analysis using a proteomic-immunohistochemical approach. (PubMed, Virchows Arch)
    The tumour microenvironment of LUAD in patients with UIP harbours distinct characteristics, including altered CAF markers and increased inflammatory cell infiltration in stromal components. Novel stromal proteins such as ACAN and HAPLN1 may play a role in the pathogenesis of LUAD with UIP.
    Journal
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    CD8 (cluster of differentiation 8) • FOXP3 (Forkhead Box P3) • ACAN (Aggrecan) • HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1)
    9ms
    HAPLN1 secreted by synovial fibroblasts in rheumatoid arthritis promotes macrophage polarization towards the M1 phenotype (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    Notably, the introduction of rHAPLN1 in rescue experiments further promoted Mϕ polarization towards the M1 phenotype. Conclusion HAPLN1, secreted by RA fibroblast-like synoviocytes (RA-FLS), enhances Mϕ polarization towards the M1 phenotype.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1)
    9ms
    Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto's thyroiditis. (PubMed, Clin Exp Med)
    Our study also highlighted the involvement of CLTA and EDIL3 in activating the Rap1 signaling pathway, crucial for cancer cell migration, proliferation, and invasion. These findings emphasize the potential of CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets for TC and HT.
    Journal
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    HIP1 (Huntingtin Interacting Protein 1) • EDIL3 (EGF Like Repeats And Discoidin Domains 3) • HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1)
    almost3years
    HAPLN1 potentiates peritoneal metastasis in pancreatic cancer. (PubMed, Nat Commun)
    Extracellular HAPLN1 modifies cancer cells and fibroblasts, rendering them more immunomodulatory. As such, we identify HAPLN1 as a prognostic marker and as a driver for peritoneal metastasis in PDAC.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1)