H3-5 (H3.5 Histone)

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4ms

Molecular Characterization of Seminoma Utilizing the AACR Project GENIE: A Retrospective Observational Study. (PubMed, Cancers (Basel))

This study provided a comprehensive molecular and genetic profiling of seminoma including key genetic alterations, affected pathways, and potential therapeutic strategies. Moreover, overlap between pathways and gene mutations provides the potential for alternative treatment options for seminoma via multiple pathways.

4 months ago

Observational data • Retrospective data • Journal

EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ALK (Anaplastic lymphoma kinase) • AXL (AXL Receptor Tyrosine Kinase) • KMT2C (Lysine Methyltransferase 2C) • STAG2 (Stromal Antigen 2) • CCND2 (Cyclin D2) • PMS1 (PMS1 protein homolog 1) • BRD4 (Bromodomain Containing 4) • AMER1 (APC Membrane Recruitment Protein 1) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • H3-5 (H3.5 Histone)

KRAS mutation

8ms

Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types. (PubMed, Sci Rep)

Among the ML models, SVM stood out, exhibiting classification success between HER2 + and TNBC transcriptomes with an accuracy of 90%. The findings of this study can therefore effectively aid in tracing the initial prognosis of BC and identify biomarkers for the personalized prevention, prediction, diagnosis, and treatment of BC.

8 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • ER (Estrogen receptor) • TP53 (Tumor protein P53) • PGR (Progesterone receptor) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • H3-5 (H3.5 Histone) • HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) • SIRT1 (Sirtuin 1)

1year

Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones. (PubMed, Sci Rep)

Furthermore, we identified physical interactions between H3.5 and histone chaperones Asf1a and Asf1b, HIRA, CAF p150 and DAXX, shedding light on the protein-level regulation of H3.5. These findings provide valuable insights into the molecular mechanisms governing testicular cell differentiation and the potential role of H3.5 in testicular pathologies.

1 year ago

Journal

ASF1B (Anti-Silencing Function 1B Histone Chaperone) • DAXX (Death-domain associated protein) • H3-5 (H3.5 Histone)

over1year

Exploring the protective effect and mechanism of icariside II on the bladder in a rat model of radiation cystitis based on transcriptome sequencing. (PubMed, Int J Radiat Biol)

ICAII may alleviate the bladder inflammatory response and inhibit the fibrosis process of bladder tissues through the regulation of H3F3C, ISG15, SPP1, and LCN2 targets and has a protective effect on the bladder of radioinjured rats. In particular, H3F3C may be one of the most promising therapeutic targets.

over 1 year ago

Preclinical • Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • SPP1 (Secreted Phosphoprotein 1) • IL10 (Interleukin 10) • H3-5 (H3.5 Histone) • IL1B (Interleukin 1, beta) • IL4 (Interleukin 4) • ISG15 (ISG15 Ubiquitin Like Modifier)

over1year

Comprehensive next-generation sequencing identifies novel putative pathogenic or likely pathogenic germline variants in patients with concurrent tubo-ovarian and endometrial serous and endometrioid carcinomas or precursors. (PubMed, Gynecol Oncol)

Comprehensive germline testing of patients with concurrent LGEEA or CAH and ESC, HGSC or precursor lesions may aid in early identification of relatives at-risk for cancer who may be candidates for RRSO with hysterectomy.

over 1 year ago

Journal • Next-generation sequencing

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1) • GLI1 (GLI Family Zinc Finger 1) • INPP4B (Inositol polyphosphate-4-phosphatase type II B) • FOXP1 (Forkhead Box P1) • FANCD2 (FA Complementation Group D2) • H3-5 (H3.5 Histone)