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    GENE:

    H2AZ2 (H2A.Z Variant Histone 2)

    i
    Other names: H2AZ2, H2A.Z Variant Histone 2, H2AFV, H2AV, H2A Histone Family Member V, Histone H2A.V, MGC10170, MGC10831, MGC1947, H2A.F/Z, Purine-Rich Binding Element Protein B, H2A Histone Family, Member V, Histone H2A.F/Z, H2A.Z-2
    Associations

    News

    Trials
    1year
    Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk. (PubMed, Prostate)
    The identified blood-based candidate susceptibility genes provide further insights into the genetic basis of PCa risk.
    Journal
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    GSTP1 (Glutathione S-transferase pi 1) • LMNA (Lamin A/C) • EP300 (E1A binding protein p300) • PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta) • SECTM1 (Secreted and transmembrane 1) • TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) • TRAF1 (TNF Receptor Associated Factor 1) • H2AZ2 (H2A.Z Variant Histone 2) • MAPK3 (Mitogen-Activated Protein Kinase 3) • NKX3-1 (NK3 homeobox 1)
    over1year
    Identification of a lactylation-related gene signature to characterize subtypes of hepatocellular carcinoma using bulk sequencing data. (PubMed, J Gastrointest Oncol)
    Strong correlation between LRGs and tumor classification as well as immunity in patients with HCC was identified. LRG signatures serve as reliable prognostic markers for HCC.
    Journal • Gene Signature • IO biomarker
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    CD8 (cluster of differentiation 8) • SF3B1 (Splicing Factor 3b Subunit 1) • CD4 (CD4 Molecule) • HDAC2 (Histone deacetylase 2) • HDAC1 (Histone Deacetylase 1) • HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) • ALYREF (Aly/REF Export Factor) • H2AZ2 (H2A.Z Variant Histone 2)
    2years
    Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway. (PubMed, Biochem Pharmacol)
    Furthermore, in vivo assays validated the inhibitory role of ISL in melanoma proliferation and the expression of H2A.Z.1 and E2F1.Aboveall,it is indicated that ISL inhibit melanoma proliferation via targeting H2A.Z.1-E2F1 pathway. These findings explain the anti-tumor mechanism of ISL and provide potential therapeutic targets for melanoma.
    Journal
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    E2F1 (E2F transcription factor 1) • H2AZ2 (H2A.Z Variant Histone 2)
    over3years
    Oncogenic Role of HMGB1 as An Alarming in Robust Prediction of Immunotherapy Response in Colorectal Cancer. (PubMed, Cancers (Basel))
    HMGB1 is a potential novel biomarker for improving clinical prognosis and antitumor immunotherapy efficacy. CDK1, HMGB2, SSRP1, and H2AFV may serve as key nodes for HMGB1 in colorectal cancer.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • HMGB1 (High Mobility Group Box 1) • CDK1 (Cyclin-dependent kinase 1) • H2AZ2 (H2A.Z Variant Histone 2) • HMGB2 (High Mobility Group Box 2) • SSRP1 (Structure Specific Recognition Protein 1)
    over3years
    Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in HNSCC. (PubMed, Cancer Sci)
    In addition, METTL3/14 knockdown decreased IFT80 expression. Thus, our findings suggested that lnc-H2AFV-1 might be a biomarker that alters m6A modification by regulating the m6A methylases METTL3/14 and FTO, and then mediating downstream target IFT80 to promote HNSCC progression.
    Journal
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    FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • H2AZ2 (H2A.Z Variant Histone 2) • METTL14 (Methyltransferase 14) • METTL3 (Methyltransferase Like 3)
    over3years
    GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer. (PubMed, Cell Oncol (Dordr))
    Our data indicate that GAS41 mediates proliferation and GEM resistance in pancreatic cancer cells via H2A.Z.2 and Notch1.
    Journal
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    NOTCH1 (Notch 1) • H2AZ2 (H2A.Z Variant Histone 2) • YEATS4 (YEATS domain-containing protein 4)
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    gemcitabine