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BIOMARKER:

H19 overexpression

i
Other names: H19, H19 Imprinted Maternally Expressed Transcript, H19 Imprinted Maternally Expressed Transcript (Non-Protein Coding), H19, Imprinted Maternally Expressed Untranslated MRNA, Long Intergenic Non-Protein Coding RNA 8, Adult Skeletal Muscle, NCRNA00008, LINC00008, D11S813E, MIR675HG, ASM1, ASM, Non-Protein Coding RNA 8, MIR675 Host Gene, NONHSAG007409.2, HSALNG0082178, MIR675 Host, BWS, WT2
Entrez ID:
1d
NKX2-1 gene is targeted by H19 lncRNA and is found to be overexpressed in benign nodular goiter tissues. (PubMed, Braz J Otorhinolaryngol)
NKX2-1 has been identified as the putative target of H19 lncRNA, which is overexpressed in nodular goiter tissues significantly.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript) • MIR182 (MicroRNA 182)
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H19 overexpression • NKX2-1 expression
3ms
H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer. (PubMed, Yale J Biol Med)
Overexpression of H19 in malignant tissues compared to adjacent non-malignant tissues marks H19 as an independent prognostic marker in CRC. Besides its prognostic value, H19 serves as a promising target for therapy in CRC treatment.
Review • Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
5ms
Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma. (PubMed, Nat Commun)
Spatial transcriptomics and single-nucleus RNAseq analyses identify a 60-gene signature in 11p15.5 altered hepatocytes. These data provide insights for 11p15.5 mosaicism detection and its functional consequences during the early steps of carcinogenesis.
Journal
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IGF2 (Insulin-like growth factor 2) • H19 (H19 Imprinted Maternally Expressed Transcript)
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IGF2 overexpression • H19 overexpression
6ms
Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis. (PubMed, Oncol Res)
Consistently, blockage of miR-107 activity alleviated the growth suppression phenotypes induced by H19 downregulation, suggesting that H19 serves as a molecular sponge for miR-107 to promote CDK6 expression and cell cycle progression. Together, this study demonstrates a mechanistic function of H19 in driving the proliferation of HCC cells and suggests H19 suppression as a novel approach for HCC treatment.
Journal
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CDK6 (Cyclin-dependent kinase 6) • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression • CDK6 expression
8ms
H19 recruited m6A reader YTHDF1 to promote SCARB1 translation and facilitate angiogenesis in gastric cancer. (PubMed, Chin Med J (Engl))
HIF-1α induced overexpression of H19 via binding with the promoter of H19, and H19 promoted GC cells proliferation, migration and angiogenesis through YTHDF1/SCARB1, which might be a beneficial target for antiangiogenic therapy for GC.
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • H19 (H19 Imprinted Maternally Expressed Transcript) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1)
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H19 overexpression • HIF1A expression
11ms
β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer. (PubMed, Pharmacol Res)
The high level of H19 enhanced the cytotoxicity of erlotinib by inducing ferroptosis. In conclusion, our data showed that β-elemene combined with erlotinib could enhance sensitivity to EGFR-TKIs through induction of ferroptosis via H19 in primary EGFR-TKI-resistant lung cancer, providing a promising strategy to overcome EGFR-TKI resistance in NSCLC patients.
Journal
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EGFR (Epidermal growth factor receptor) • H19 (H19 Imprinted Maternally Expressed Transcript)
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EGFR mutation • H19 overexpression
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erlotinib
over1year
LncRNA H19 Promotes Lung Adenocarcinoma Progression via Binding to Mutant p53 R175H. (PubMed, Cancers (Basel))
H19 over-expression may induce the elevated expression of mtp53 and interact with mtp53, leading to LAC progression. In addition, the high expression of mtp53 R175H is associated with poor overall survival inpatients. The simultaneous inhibition of H19 and mtp53 may provide a novel strategy for the effective control of LAC clinically.
Journal
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TP53 (Tumor protein P53) • H19 (H19 Imprinted Maternally Expressed Transcript)
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TP53 mutation • TP53 expression • H19 overexpression
over1year
HHLA2 promotes tumor progression by long non‑coding RNA H19 in human gallbladder cancer. (PubMed, Int J Oncol)
These results suggest that HHLA2 overexpression can promote GBC progression. Conversely, ablation of HHLA2 expression inhibited both TGF‑β1‑ and lncRNA H19‑induced GBC progression, suggesting that HHLA2 is a potential therapeutic target for this disease.
Journal
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CDH1 (Cadherin 1) • VIM (Vimentin) • TGFB1 (Transforming Growth Factor Beta 1) • CDH2 (Cadherin 2) • H19 (H19 Imprinted Maternally Expressed Transcript) • HHLA2 (HERV-H LTR-Associating 2) • VSIR (V-Set Immunoregulatory Receptor)
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H19 overexpression
almost2years
Long Noncoding RNA H19 Derived from M2 Tumor-Associated Macrophages Promotes Bladder Cell Autophagy via Stabilizing ULK1. (PubMed, J Oncol)
At last, we found that overexpression of exosomal H19 from TAMs suppressed the interaction between ULK1 and its specific E3 ligase NEDD4L in BC cells. We revealed the effect of TAMs-exo-contained lncRNA H19 on regulating autophagy of bladder cancer cells, which indicated that targeting TAMs-H19 is a promising therapeutic strategy for the treatment of BC.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript) • IL13 (Interleukin 13) • IL4 (Interleukin 4)
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H19 overexpression
2years
Long non-coding RNA H19 as biomarker for hepatocellular carcinoma. (PubMed, Liver Int)
LncRNA-H19 expression was increased in CSCs, in liver tissue and plasma of patients with HCC and decreased after partial/complete therapeutic response. Those patients who developed HCC during the follow-up showed higher levels of lncRNA-H19. LncRNA-H19 could constitute a new biomarker of HCC.
Journal
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EPCAM (Epithelial cell adhesion molecule) • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression • EPCAM expression
2years
Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. (PubMed, Bioact Mater)
In conclusion, our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis, and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death. Therefore, our findings will hopefully provide a valuable drug for treating lung cancer patients.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript) • MIR19B1 (MicroRNA 19b-1)
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H19 overexpression
2years
Long non-coding RNA H19 correlates with unfavorable prognosis and promotes cell migration and invasion in ovarian cancer. (PubMed, Ginekol Pol)
The key finding of the present study suggests that overexpression of H19 may be associated with an unfavorable prognosis for OC and is likely to be a possible contributory force involved in OC cell migration and invasion. H19 may provide a new and attractive target for future prognostic and therapeutic intervention of OC patients.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
2years
The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. (PubMed, Nat Commun)
Our clinical data identify H19 as a candidate diagnostic marker and predictive marker of NEPC with elevated H19 levels associated with an increased probability of biochemical recurrence and metastatic disease in patients receiving ADT. Here we report H19 as an early upstream regulator of cell fate, plasticity, and treatment resistance in NEPC that can reverse/transform cells to a treatable form of PCa once therapeutically deactivated.
Journal
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AR (Androgen receptor) • SOX2 • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
over2years
Long non-coding RNA H19 expression correlates with autophagy process in adrenocortical carcinoma. (PubMed, Cancer Invest)
The administration of the deacetylase inhibitors (DACi) panobinostat, trichostatin A and SAHA affected the cell viability of H295R monolayer and spheroids and induced the over-expression of H19 and autophagy transcripts...Neither the active protein level nor the activity of caspases 8 and 3 was prompted by the DACi, thus excluding the involvement of the executioners of apoptosis in H295R decay.The deacetylase inhibitors restore H19, the autophagy markers and trigger cell death in adrenocortical carcinoma cells. The re-activation of autophagy would represent a novel strategy for the treatment of patients affected by this severe malignancy.
Journal
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IGF2 (Insulin-like growth factor 2) • CASP8 (Caspase 8) • H19 (H19 Imprinted Maternally Expressed Transcript) • BECN1 (Beclin 1)
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IGF2 overexpression • H19 overexpression
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Zolinza (vorinostat) • Farydak (panobinostat)
over2years
Overexpression of Long Noncoding RNA H19 Inhibits Cardiomyocyte Apoptosis in Neonatal Rats with Hypoxic-Ischemic Brain Damage Through the miR-149-5p/LIF/PI3K/Akt Axis. (PubMed, Biopreserv Biobank)
It could be concluded that H19 competitively bound to miR-149-5p to upregulate LIF expression and activate the PI3K/Akt pathway, thus reducing cardiomyocyte apoptosis in neonatal rats with HIBD. This study may offer new insights for HIBD treatment.
Preclinical • Journal
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H19 (H19 Imprinted Maternally Expressed Transcript) • MIR149 (MicroRNA 149)
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H19 overexpression
over2years
Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells. (PubMed, Biomed Res Int)
Moreover, overexpression promoted tumor growth in nude mice and was suppressed by PI3K inhibitor. LncRNA H19 downregulation of miR-140-5p to activate the PI3K/AKT signaling pathway and promote the proliferation, invasion, migration and EMT of OC.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
over2years
Increased Expression of Long Non-coding RNA H19 is Associated With Colon Cancer Recurrence. (PubMed, J Surg Res)
Colon cancer H19 expression is associated with advanced stage of tumor disease and is a significant risk factor for reduced recurrence-free survival. Tumor expression of H19 may have potential for both prognostic and therapeutic uses in the future.
Journal
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KRAS (KRAS proto-oncogene GTPase) • H19 (H19 Imprinted Maternally Expressed Transcript)
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KRAS mutation • H19 overexpression • KRAS expression
over2years
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors. (PubMed, Acta Neuropathol)
Median progression-free survival was 35 months (for 11 patients with data available). In summary, our findings suggest the existence of a novel group of supratentorial neuroepithelial tumors that are characterized by recurrent PLAGL1 fusions and enriched for pediatric patients.
Clinical • Journal
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EWSR1 (EWS RNA Binding Protein 1) • EP300 (E1A binding protein p300) • IGF2 (Insulin-like growth factor 2) • SOX10 (SRY-Box 10) • FOXO1 (Forkhead box O1) • H19 (H19 Imprinted Maternally Expressed Transcript) • GFAP (Glial Fibrillary Acidic Protein)
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H19 overexpression
almost3years
H19 promotes aerobic glycolysis, proliferation and immune escape of gastric cancer cells via the miR-519d-3p/LDHA axis. (PubMed, Cancer Sci)
Moreover, conditioned medium (CM) from stable knockdown H19 GC cells modulated the activity of immune cells including γδT cells, Jurkat cells, and tumor-associated macrophages (TAMs) in a miR-519d-3p/LDHA/lactate axis dependent manner. The H19/miR-519d-3p/LDHA axis mainly contributed to aerobic glycolysis, proliferation, and immune escape of GC cells.
Journal
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LDHA (Lactate dehydrogenase A) • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
almost3years
Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis. (PubMed, Int J Mol Sci)
Lastly, we demonstrate that arecoline stimulated the upregulation of H19 through the transforming growth factor (TGF)-β pathway. Altogether, this study suggests that increased TGF-β secretion following areca nut chewing may induce the upregulation of H19, which serves as a natural sponge for miR-29b and impedes its antifibrotic effects.
Journal
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FN1 (Fibronectin 1) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • H19 (H19 Imprinted Maternally Expressed Transcript) • MIR29A (MicroRNA 29a)
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H19 overexpression
almost3years
Ginsenoside Rg3 suppresses ovarian cancer cell proliferation and invasion by inhibiting the expression of lncRNA H19. (PubMed, Acta Biochim Pol)
In terms of the mechanism, knockdown of H19 inhibited cell proliferation, migration and invasion, while overexpression of H19 reversed the inhibitory effect of Rg3 on the OC cells. In conclusion, ginsenoside Rg3 suppresses the proliferation, migration and invasion of OC cells by partially inhibiting the expression of lncRNA H19.
Journal
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CDH1 (Cadherin 1) • H19 (H19 Imprinted Maternally Expressed Transcript)
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CDH1 expression • H19 overexpression
3years
Long Noncoding RNA H19 Overexpression Protects against Hypoxic-Ischemic Brain Damage by Inhibiting miR-107 and Up-Regulating Vascular Endothelial Growth Factor. (PubMed, Am J Pathol)
H19 overexpression decreased miR-107 and increased VEGF expression, which resulted in repressed neuronal apoptosis and alleviated cognitive dysfunction. Thus, H19 may serve as a molecular target for translational research for HIBD therapy.
Journal
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BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3) • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression • VEGFA expression
3years
Long noncoding RNA H19 contributes to the proliferation and autophagy of glioma cells through mTOR/ULK1 pathway. (PubMed, Neuroreport)
H19 promoted proliferation, migration, and autophagy by regulating mTOR signaling. In conclusion, we validate that H19 contributes to the proliferation and autophagy of glioma cells through the mTOR/ULK1 pathway.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
3years
Roles of the H19/microRNA‑675 axis in the proliferation and epithelial‑mesenchymal transition of human cutaneous squamous cell carcinoma cells. (PubMed, Oncol Rep)
Conversely, the genetic silencing of H19 or miR‑675 inhibited proliferation and invasion in SCL1 and A431 cSCC cell lines. In conclusion, the findings of the present study provided novel insight into the potential role of H19 and miR‑675 in the development, metastasis and progression of cSCC, which may help the development of treatments for cSCC.
Journal
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TP53 (Tumor protein P53) • H19 (H19 Imprinted Maternally Expressed Transcript)
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TP53 expression • H19 overexpression
3years
H19 Promotes HCC Bone Metastasis Through Reducing OPG Expression in a PPP1CA/p38MAPK-Dependent Manner and Sponging miR-200b-3p. (PubMed, Hepatology)
Additionally, H19 enhanced cell migration and invasion by upregulating zinc finger E-box binding homeobox 1 (ZEB1) via the sequestration of miR-200b-3p. H19 plays a critical role in HCC bone metastasis by reducing OPG expression, which is mediated by the PPP1CA-induced inactivation of the p38MAPK pathway, and H19 also functions as a sponge for miR-200b-3p.
Journal
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MIR200B (MicroRNA 200b) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
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H19 overexpression
3years
H19 Rises in Gastric Cancer and Exerts a Tumor-Promoting Function via miR-138/E2F2 Axis. (PubMed, Cancer Manag Res)
H19 can be used as a biological indicator for diagnosing GC and predicting patients' poor prognosis. Additionally, it promotes GCCs to proliferate and invade through miR-138/E2F2 axis.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
over3years
FOXF2 aggravates the progression of non-small cell lung cancer through targeting lncRNA H19 to downregulate PTEN. (PubMed, Eur Rev Med Pharmacol Sci)
FOXF2 was upregulated in NSCLC. It accelerated the proliferative and migratory abilities of the NSCLC cells by targeting H19 to downregulate PTEN, thus aggravating the progression of NSCLC.
Journal
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PTEN (Phosphatase and tensin homolog) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • H19 (H19 Imprinted Maternally Expressed Transcript)
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EZH2 overexpression • H19 overexpression • EZH2 positive
over3years
Curcumin attenuates lncRNA H19‑induced epithelial‑mesenchymal transition in tamoxifen‑resistant breast cancer cells. (PubMed, Mol Med Rep)
The present study indicated that H19 may serve as a promoting factor of EMT, invasion and migration in MCF‑7/TAMR cells, suggesting that curcumin may prevent H19‑associated metastasis. Therefore, curcumin may serve as a promising therapeutic drug for patients with TAMR breast cancer.
Journal
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CDH1 (Cadherin 1) • H19 (H19 Imprinted Maternally Expressed Transcript)
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CDH1 expression • H19 overexpression
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tamoxifen
over3years
Long noncoding RNA H19 promotes vincristine resistance in multiple myeloma by targeting Akt. (PubMed, Cell Mol Biol (Noisy-le-grand))
Lnc-RNA H19 overexpression plasmid pcdna3.1-h19 and Akt overexpression plasmid pcdna3.1-akt decreased apoptosis in RPMI 8226 cell lines without VCR resistance (***p<0.001), while the recombination of siRNA-h19 and siRNA-akt plasmid increased apoptosis in RPMI 8226-VCR (***p<0.001). The lnc-RNA H19/Akt pathway is closely related to the occurrence of VCR resistance in MM cells, and the down-regulation of H19 can significantly improve the sensitivity of VCR in MM.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
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vincristine
over3years
Transcription factor HIF1α promotes proliferation, migration and invasion of cholangiocarcinoma via long non-coding RNA H19/microRNA-612/Bcl-2 axis. (PubMed, Transl Res)
Overexpression of miR-612 could rescue the proliferation, migration and invasion of cholangiocarcinoma cells caused by lncRNA H19 overexpression. Taken together, HIF1α activated lncRNA H19-mediated miR-612/Bcl-2 pathway to promote cholangiocarcinoma, suggesting a promising therapeutic target for cholangiocarcinoma.
Journal
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BCL2 (B-cell CLL/lymphoma 2) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression • HIF1A expression
over3years
LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19. (PubMed, J Cell Biochem)
Cancer cell migration and invasion were not significantly affected by PTCSC3 overexpression. Therefore, lncRNA PTCSC3 inhibits TNBC cell proliferation by downregulating lncRNA H19.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
over3years
Long noncoding RNA H19 acts as a miR-340-3p sponge to promote epithelial-mesenchymal transition by regulating YWHAZ expression in paclitaxel-resistant breast cancer cells. (PubMed, Environ Toxicol)
Besides, bioinformatics tools and dual-luciferase reporters assays indicated that miR-340-3p could act as a potential target gene of H19, the underlying mechanism studies proved that H19 could act as a competing endogenous RNA (ceRNA) via competitively binding miR-340-3p to promote BC cell proliferation, metastasis and EMT by regulating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) and potentiate the Wnt/β-catenin signaling in BC cells. In summary, our findings demonstrated that H19 could act as a ceRNA in BC progression, metastasis and EMT through modulating miR-340-3p/YWHAZ axis and activating the canonical Wnt/β-catenin signaling pathway, indicating that H19 might act as an underlying therapeutic target and prognostic biomarker for BC therapy.
Journal
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H19 (H19 Imprinted Maternally Expressed Transcript)
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H19 overexpression
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paclitaxel